Evidence map›Paper›PMID 40539050›Full record

ArticleFrontiers in immunology2025

The fusion subunit vaccine L-DBF protects aged mice against heterologous lethal

Md Shafiullah Parvej, Ti Lu, Suhrid Maiti, Zackary K Dietz, Debaki R Howlader, Mst Nusrat Zahan, Alexa Cato, Satabdi Biswas, William D Picking, Wendy L Picking

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Md Shafiullah ParvejBond Life Sciences Center and the Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.
Ti LuBond Life Sciences Center and the Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.
Suhrid MaitiBond Life Sciences Center and the Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.
Zackary K DietzBond Life Sciences Center and the Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.
Debaki R HowladerBond Life Sciences Center and the Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.
Mst Nusrat ZahanBond Life Sciences Center and the Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.
Alexa CatoBond Life Sciences Center and the Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.
Satabdi BiswasBond Life Sciences Center and the Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.
William D PickingBond Life Sciences Center and the Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.
Wendy L PickingBond Life Sciences Center and the Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shigellosis is among the top causes of bacterial diarrhea with significantly high morbidity and mortality for children under five years of age in low- and middle-income countries. Unfortunately, there are currently no licensed vaccines to prevent shigellosis. Our laboratory has developed the protein-based subunit vaccine candidate L-DBF by fusing the type III secretion system proteins IpaB and IpaD with the mucosal adjuvant LTA1, the active moiety of the heat-labile toxin from enterotoxigenic

Indexed as

Antigens, BacterialDysentery, BacillaryEnterotoxinsEscherichia coli ProteinsShigellaShigella flexneriShigella sonneiShigella VaccinesAnimalsAntibodies, BacterialBacterial ProteinsBacterial ToxinsCross ProtectionDisease Models, AnimalFemaleHumansAntibodies, BacterialAntigens, BacterialBacterial ProteinsBacterial ToxinsEnterotoxinsEscherichia coli Proteinsheat-labile enterotoxin, E coliipaB protein, ShigellaIpaD protein, Shigella flexneriRecombinant Fusion ProteinsShigella VaccinesVaccines, Subunitaged miceintranasal vaccinationpre-exposureShigellasubunit vaccine

Identifiers

PMID40539050
PMCPMC12176820

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.