ReviewCureus2025
Association Between Metabolic Syndrome and Subclinical Hypothyroidism: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Thyroid Hormones and Metabolic Syndrome: A Narrative Review of Findings from 18 Years of Follow-up in Tehran Thyroid Study (TTS).International journal of endocrinology and metabolism · 2026Review
- Modulation of metabolic syndrome components by oral semaglutide in hypothyroid-T2DM patients: a retrospective analysis.Journal of medicine and life · 2025Article
- Incidence of Subclinical Hypothyroidism in Obese Adults and Its Metabolic Implications: A Prospective Cohort Study.Cureus · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic syndrome (MetS) and subclinical hypothyroidism (SCH) are prevalent endocrine-metabolic disorders with significant cardiovascular implications. Emerging evidence suggests a bidirectional relationship between these conditions, but findings remain inconsistent across populations. This systematic review synthesizes existing literature to evaluate the association between SCH and MetS, focusing on prevalence, demographic variations, and mechanistic links. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive search was conducted across PubMed, Scopus, Web of Science, and Embase up to April 2025. Twelve observational studies (cross-sectional, cohort, and case-control) were included after screening. Studies were selected based on predefined criteria: adult populations (≥18 years), clear definitions of SCH (elevated thyroid-stimulating hormone (TSH) with normal free thyroxine 4 (FT4)) and MetS (National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), International Diabetes Federation (IDF), or Joint Interim criteria). Data were extracted on study characteristics, prevalence rates, and metabolic associations. Quality assessment used the Newcastle-Ottawa Scale. SCH prevalence was significantly higher in MetS patients (range 8.9-37%) as compared to controls, with notable geographic and gender disparities. Key findings included: (1) Strong associations between SCH and central obesity, dyslipidemia, and hypertension; (2) Gender-specific risks, with males showing higher MetS incidence and females exhibiting higher SCH prevalence; (3) Age-related trends, with SCH prevalence increasing with age, though no elevated risk was observed in individuals ≥50 years. Longitudinal data suggested MetS may predict SCH development. This review supports a significant association between SCH and MetS, driven by shared pathways involving lipid metabolism, insulin resistance, and adiposity. Demographic variations underscore the need for tailored screening, particularly in high-risk groups. Standardized diagnostic criteria and prospective studies are warranted to clarify causality and therapeutic implications.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.