ArticleCureus2025
Two Cases of Crovalimab-Induced Platelet Recovery in Bone Marrow Failure-Associated Paroxysmal Nocturnal Hemoglobinuria (PNH).
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired clonal hematopoietic stem cell disorder caused by phosphatidylinositol N-acetylglucosaminyltransferase subunit A (PIG-A) gene mutations, leading to complement-mediated hemolysis, cytopenias, and thrombotic risk. While C5 inhibitors, such as eculizumab and ravulizumab, have transformed PNH management, optimal strategies for bone marrow failure-associated PNH remain unclear. We report two cases of bone marrow failure-associated PNH treated with crovalimab, focusing on its effects on hemolysis and blood cell recovery, particularly platelet counts within four weeks of crovalimab initiation. Case 1: A 79-year-old man presented with mild anemia, thrombocytopenia, elevated LDH, and impaired renal function. Crovalimab initiation resulted in rapid symptom improvement, decreased LDH, and a platelet increase. Case 2: A 22-year-old male athlete exhibited mild anemia, thrombocytopenia, and elevated LDH. Crovalimab resolved the symptoms, there were no hemolytic attacks, and the platelet count increased. Both patients demonstrated prompt improvement in hemolytic parameters and significant platelet recovery following crovalimab initiation, with no serious adverse events. These findings suggest that crovalimab not only attenuates hemolysis but may also improve platelet counts in bone marrow failure-associated PNH, highlighting its broader therapeutic potential and the need for further investigation in larger cohorts.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.