ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
A Nano-Electro-Platform Enabling Evolutionary Screening and Remodeling of Tumor Cells for Metastasis Inhibition.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A Nano-Electro-Platform Enabling Evolutionary Screening and Remodeling of Tumor Cells for Metastasis Inhibition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Current perspectives and global trends of nanotechnology in advanced breast cancer: a bibliometric and visualized analysis.Discover oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
Tumor metastasis remains the leading cause of mortality among cancer patients. Addressing this challenge necessitates the development of effective strategies for targeted drug delivery and therapy. Given that metastatic lesions are primarily driven by highly aggressive tumor cell subpopulations, in-depth study of these cells and further guiding design of targeted therapeutics, play deterministic roles in metastasis inhibition. Herein, a nano-electro-platform is shown that enables non-invasive screening of aggressive cell subpopulations from heterogeneous tumor samples. Single-cell sequencing further reveals immune evasion pathways associated with their aggressive behavior. Targeting the screened aggressive cells, the platform implements a unique nanopore-focused electric field, which genetically remodels the cells to generate extracellular vesicles (EVs) with significantly enhanced tumor-targeting and therapeutic capabilities. The engineered EVs effectively activate macrophages and T cells, leading to robust tumor cell elimination and metastasis inhibition in lung cancer metastasis models. These highlight a versatile, multidisciplinary technique adopting a new path toward deep understanding and treating metastasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.