Evidence map›Paper›PMID 40539474›Full record

ArticleThe Kaohsiung journal of medical sciences2025

Effects of Sofosbuvir/Velpatasvir Therapy on Extrahepatic Manifestations in Patients With Type 2 Diabetes and Chronic Hepatitis C: Insights From a Nationwide Hepatitis C Virus Registry in Taiwan.

Szu-Jen Wang, Te-Sheng Chang, Ching-Chu Lo, Chao-Hung Hung, Chien-Wei Huang, Lee-Won Chong, Pin-Nan Cheng, Ming-Jong Bair, Ming-Lun Yeh, Cheng-Yuan Peng and 34 more

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Article in The Kaohsiung journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Szu-Jen WangGraduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Te-Sheng ChangDivision of Hepatogastroenterology, Department of Internal Medicine, ChiaYi Chang Gung Memorial Hospital, Chiayi, Taiwan.
Ching-Chu LoDivision of Gastroenterology, Department of Internal Medicine, St. Martin De Porres Hospital, Chiayi, Taiwan.
Chao-Hung HungDivision of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0003-1646-9519
Chien-Wei HuangDivision of Gastroenterology, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan.
Lee-Won ChongDivision of Hepatology and Gastroenterology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Pin-Nan ChengDivision of Gastroenterology and Hepatology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Ming-Jong BairDivision of Gastroenterology, Department of Internal Medicine, Taitung Mackay Memorial Hospital, Taitung, Taiwan.ORCID https://orcid.org/0000-0001-7069-5459
Ming-Lun YehHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0003-3728-7618
Cheng-Yuan PengCenter for Digestive Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.ORCID https://orcid.org/0000-0001-9030-6086
Chien-Yu ChengDivision of Infectious Diseases, Department of Internal Medicine, Taoyuan General Hsopital, Ministry of Health and Welfare, Taoyuan, Taiwan.
Jee-Fu HuangHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-2752-7051
Chih-Lang LinLiver Research Unit, Department of Hepato Gastroenterology and Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, College of Medicine, Chang Gung University, Keelung, Taiwan.
Chi-Chieh YangDepartment of Gastroenterology, Division of Internal Medicine, Show Chwan Memorial Hospital, Changhua, Taiwan.
Hsing-Tao KuoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
Tsai-Yuan HsiehDivision of Gastroenterology, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Tzong-Hsi LeeDivision of Gastroenterology and Hepatology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Pei-Lun LeeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan.
Wen-Chih WuWen-Chih Wu Clinic, Fengshan, Kaohsiung, Taiwan.
Chih-Lin LinDepartment of Gastroenterology, Renai Branch, Taipei City Hospital, Taipei, Taiwan.
Wei-Wen SuDepartment of Gastroenterology and Hepatology, Changhua Christian Hospital, Changhua, Taiwan.
Sheng-Shun YangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Chia-Chi WangTaipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and School of Medicine, Tzu Chi University, Taipei, Taiwan.
Jui-Ting HuLiver Center, Cathay General Hospital, Taipei, Taiwan.
Lein-Ray MoDivision of Gastroenterology, Tainan Municipal Hospital (Managed By Show Chwan Medical Care Corporation), Tainan, Taiwan.ORCID https://orcid.org/0000-0003-4167-9438
Chun-Ting ChenDivision of Gastroenterology, Department of Internal Medicine tri Service, General Hospital Penghu Branch, National Defense Medical Center, Taipei, Taiwan.
Yi-Hsiang HuangDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Chun-Chao ChangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
Chia-Sheng HuangYang Ming Hospital, Chiayi, Taiwan.
Guei-Ying ChenPenghu Hospital, Ministry of Health and Welfare, Penghu, Taiwan.
Chien-Neng KaoNational Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.ORCID https://orcid.org/0000-0003-4368-7052
Chi-Ming TaiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-1605-3516
Chun-Jen LiuHepatitis Research Center and Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Mei-Hsuan LeeInstitute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Pei-Chien TsaiHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-5044-6727
Shu-Chi WangHepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0001-9691-7507
Chia-Yen DaiHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0003-2296-3054
Jia-Horng KaoHepatitis Research Center and Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Han-Chieh LinDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Wang-Long ChuangHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-2376-421X
Kuo-Chih TsengSchool of Medicine, Tzuchi University, Hualien, Taiwan.ORCID https://orcid.org/0000-0002-4811-3018
Chi-Yi ChenDivision of Gastroenterology and Hepatology, Department of Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan.
Chung-Feng HuangHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-3367-068X
Ming-Lung YuHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0001-8145-1900

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study examines the impact of hepatitis C virus (HCV) eradication through sofosbuvir/velpatasvir (SOF/VEL) treatment on glycated hemoglobin (HbA1c) levels in patients with chronic hepatitis C and type 2 diabetes mellitus (T2DM). Utilizing data from the Taiwan HCV Registry, a retrospective analysis was conducted on 2180 patients who met the inclusion criteria, 695 of whom had T2DM. HbA1c levels significantly decreased in the diabetes group from 7.32% ± 1.72% at baseline to 6.87% ± 1.34% after achieving sustained virological response (SVR12). Patients with higher baseline HbA1c levels and cirrhosis experienced more pronounced HbA1c reductions. Among diabetic patients with HbA1c levels ≥ 6.5, 24.6% achieved levels < 6.5 following HCV elimination, while 24.4% of prediabetic patients observed HbA1c reductions < 5.7. Multivariate analysis identified fasting glucose levels and diabetes status as significant factors associated with HbA1c decline. These findings suggest that successful HCV treatment can improve glycemic control, highlighting the need for collaboration between hepatology and non-hepatology specialists in patient care.

Indexed as

Antiviral AgentsCarbamatesDiabetes Mellitus, Type 2Hepatitis C, ChronicHeterocyclic Compounds, 4 or More RingsSofosbuvirAgedBenzimidazolesBenzopyransFemaleGlycated HemoglobinHepacivirusHumansLiver CirrhosisMaleMiddle AgedAntiviral AgentsBenzimidazolesBenzopyransCarbamatesGlycated Hemoglobinhemoglobin A1c protein, humanHeterocyclic Compounds, 4 or More RingsSofosbuvirvelpatasvirchronic hepatitis CHbA1creal‐worldTaiwantype 2 diabetes mellitus

Identifiers

PMID40539474
PMCPMC12622454

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.