ArticleThe Journal of international medical research2025
Mendelian randomization analysis of gut microbiota-driven immune modulation in rheumatoid arthritis: New mechanistic insights and therapeutic targets.
Article in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ObjectiveTo explore the complex interactions between gut microbiota and immune cell phenotypes in rheumatoid arthritis development and identify potential therapeutic targets within the gut microbiota-immune cell axis.MethodsWe conducted a Mendelian randomization analysis to explore the causal relationship between gut microbiota and rheumatoid arthritis, including the role of immune cell mediators. Sensitivity analyses assessed pleiotropy and heterogeneity, while mediation analysis identified pathways through which immune cells mediate gut microbiota effects on rheumatoid arthritis development. Key microbial taxa and their effects on rheumatoid arthritis were quantified.ResultsOur analysis identified 27 gut microbiota taxa significantly associated with rheumatoid arthritis, with
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