Evidence map›Paper›PMID 40540141›Full record

ArticleInternational ophthalmology2025

Bilateral, recurrent Cytomegalovirus retinitis in Dyskeratosis congenita healing with extensive dystrophic calcification.

Mannat Giran, Vishal Jadhav, Anamika Patel, Anup Kelgaonkar, Avinash Pathengay

Abstract readCase Reports
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In one paragraph

Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mannat GiranUveitis, Vitreous and Retina Services, LV Prasad Eye Institute, Mithu Tulsi Chanrai Campus, Bhubaneswar, Odisha, 751024, India.
Vishal JadhavUveitis, Vitreous and Retina Services, LV Prasad Eye Institute, GMR Varalaxmi Campus, Visakhapatnam, Andhra Pradesh, India.
Anamika PatelUveitis and Scleritis Service, Moorfields Eye Hospital, 162 City Rd, London, EC1V 2PD, UK.
Anup KelgaonkarUveitis, Vitreous and Retina Services, LV Prasad Eye Institute, Mithu Tulsi Chanrai Campus, Bhubaneswar, Odisha, 751024, India. anupnk2008@gmail.com.
Avinash PathengayUveitis, Vitreous and Retina Services, LV Prasad Eye Institute, GMR Varalaxmi Campus, Visakhapatnam, Andhra Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report a case of bilateral, recurrent, Cytomegalovirus (CMV) retinitis in Dyskeratosis Congenita (DKC) healing with rapid calcifications.

methodsa case report.

resultsCase report: A 25-year-old man diagnosed with DKC, having severe bone marrow hypoplasia, presented with recurrence of CMV retinitis in both eyes. He was treated four months back for CMV retinitis with systemic and bilateral intravitreal antiviral therapy for eight weeks. Dilated fundus examination showed large areas of retino-choroidal scarring with refractile calcific deposits suggestive of calcific dystrophy within healed retinitis lesions. At the margins of these healed lesions, eruptions of new granular retinitis were seen. After restarting intravitreal anti-viral therapy, these lesions showed a rapid response and healed with retinal atrophy and new calcific deposits within a few weeks. These calcium deposits were visualised as hyper-reflective deposits in atrophic retinal layers on optical coherence tomography. Despite resolution, the final visual acuity was associated with visual morbidity owing to calcification of retinitis lesions. He developed septic shock and disseminated intravascular coagulation, leading to his unfortunate demise during treatment.

conclusionThis case highlights recurrent CMV retinitis with rapid presumed dystrophic calcification in Dyskeratosis congenita with progressive bone marrow hypoplasia.

Indexed as

CalcinosisCytomegalovirus RetinitisDyskeratosis CongenitaAdultAntiviral AgentsFluorescein AngiographyFundus OculiHumansMaleRecurrenceTomography, Optical CoherenceVisual AcuityAntiviral AgentsCMV retinitisDyskeratosis congenitaDystrophic calcificationRecurrence

Identifiers

PMID40540141

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.