Evidence map›Paper›PMID 40540393›Full record

ArticleCell reports2025

Patterns of pathological tau deposition reflect the dynamics of cortical brain activity.

Feng Han, Xi Chen, Alice Murphy, JiaQie Lee, Jacob Ziontz, Susan M Landau, Suzanne L Baker, Theresa M Harrison, William J Jagust

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Feng HanDepartment of Neuroscience, University of California, Berkeley, Berkeley, CA, USA. Electronic address: feng.han@berkeley.edu.
Xi ChenDepartment of Neuroscience, University of California, Berkeley, Berkeley, CA, USA; Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Alice MurphyDepartment of Neuroscience, University of California, Berkeley, Berkeley, CA, USA.
JiaQie LeeDepartment of Neuroscience, University of California, Berkeley, Berkeley, CA, USA.
Jacob ZiontzDepartment of Neuroscience, University of California, Berkeley, Berkeley, CA, USA.
Susan M LandauDepartment of Neuroscience, University of California, Berkeley, Berkeley, CA, USA.
Suzanne L BakerLawrence Berkeley National Laboratory, Berkeley, CA, USA.
Theresa M HarrisonDepartment of Neuroscience, University of California, Berkeley, Berkeley, CA, USA.
William J JagustDepartment of Neuroscience, University of California, Berkeley, Berkeley, CA, USA; Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MONICA G. RIVERA-MINDT · 2016 to 2026
$226.7M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Neural and Biochemical Mechanisms of Cognitive AgingR01AG034570 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI William J. Jagust · 2009 to 2026
$12.0M
Mechanisms of Alzheimer's Disease Progression in the Aging BrainR01AG062542 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI JAGUST, WILLIAM J. · 2019 to 2023
$4.2M
Linking basal forebrain and entorhinal cortex vulnerability to preclinical Alzheimer's diseaseK01AG078443 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI Theresa M. Harrison · 2022 to 2026
$656k
Functional networks underlying cognitive decline in aging and Alzheimer's diseaseF31AG079595 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI ZIONTZ, JACOB · 2022 to 2023
$86k
NIA NIH HHS F31 AG079595NIA NIH HHS K01 AG078443NIA NIH HHS R01 AG034570NIA NIH HHS R01 AG062542NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG024904
6 · The paper itself

Abstract

Cortical tau deposition begins in higher-order association regions and spreads to lower-order primary sensory-motor networks in moderate/advanced Alzheimer's dementia. The neural mechanisms underlying this spatiotemporal pattern remain elusive. Initial evidence has shown that coupled dynamic, low-frequency (<0.1 Hz) brain activity in cerebrospinal fluid (CSF) flow and gray matter (global brain-CSF coupling) might be related to CSF clearance and thus β-amyloid accumulation. Here, we report that tau deposition in higher-order regions, particularly individuals with evaluated β-amyloid, is related to decreased global brain-CSF coupling in humans. Brain dynamics manifesting as propagating waves between higher- and lower-order regions mediate the association between tau and global brain-CSF coupling. Preferential tau deposition in higher-order regions is associated with weaker activation strength there during propagation and less involvement in global brain activity and CSF inflow. The findings suggest an important role of dynamic, spontaneous global brain activity in Alzheimer's tau pathology and cognition.

Indexed as

Alzheimer DiseaseBrainCerebral Cortextau ProteinsAgedAmyloid beta-PeptidesFemaleHumansMaleMiddle AgedAmyloid beta-Peptidestau ProteinsAlzheimer’s disease pathologycerebrospinal fluidCP: NeuroscienceCSFCSF clearanceCSF flowglobal resting-state fMRI signalhigh-order association regionpropagating wave of brain activitytau deposition

Identifiers

PMID40540393
PMCPMC12356599

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.