Evidence map›Paper›PMID 40542398›Full record

ArticleJournal of nanobiotechnology2025

Bionic bearing-inspired lubricating microspheres with Immunomodulatory effects for osteoarthritis therapy.

Xu He, Xingzhi Liu, Xinyi Cheng, Can Zhu, Yida Chen, Yi Wang, Yun Zhou, Hao Shen, Huilin Yang, Yong Xu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xu HeDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Medical College of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, P. R. China.
Xingzhi LiuRui Jin Hospital, Lu Wan Branch, Shanghai Jiao Tong University School of Medicine, NO.149 South Chongqing Road, Shanghai, 200000, P. R. China.
Xinyi ChengDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Medical College of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, P. R. China.
Can ZhuDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Medical College of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, P. R. China.
Yida ChenDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Medical College of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, P. R. China.
Yi WangDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Medical College of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, P. R. China.
Yun ZhouDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Medical College of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, P. R. China.
Hao ShenDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Medical College of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, P. R. China.
Huilin YangDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Medical College of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, P. R. China.
Yong XuDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Medical College of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, P. R. China. yxu1615@suda.edu.cn.
Qin ShiDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Medical College of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, P. R. China. shiqin@suda.edu.cn.
Junjie NiuDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Medical College of Soochow University, 899 Pinghai Road, Suzhou, 215031, Jiangsu, P. R. China. niujunjie1129@suda.edu.cn.

Funding

Key Laboratory of Orthopaedics of Suzhou SZS2022017National Natural Science Foundation of China 82172485, 82372457, 82472426Orthopaedic Medical Innovation Center of Jiangsu CXZX202209Technology Innovation on Medicine and Health of Suzhou Science and Technology Bureau SKY2022041, SKY2023147, SSD2024028
6 · The paper itself

Abstract

Inflammatory infiltration and inappropriate friction remain the two main challenges in treating osteoarthritis (OA). An effective treatment platform is anticipated to lubricate the cartilage and ameliorate intra-articular inflammation. Herein, injectable hydrogel microspheres with chondroitin sulfate (Chs)/sericin methacryloyl (SerMA) designed as the core and grafted with folic acid (FA)- and 78c-modified liposomes (78c@Lipo-FA) by DSPE-PEG2k-GPLGLAGQC (DPG) peptides, namely LFDCS, was formed by thin-film hydration and microfluidic methods. Physically, LFDCS exhibited cartilage lubrication and adhesion capability as the bionic bearings. Meanwhile, with the degradation of LFDCS, Chs were set out to promote chondrocyte function. Physiologically, 78c@Lipo-FA were released from LFDCS enzymatically responsible to matrix metalloprotein-9 (MMP9) due to the split of DPG motif, which specifically bound to classical-activated macrophages (M1) by ligating to FA receptor through FA and inhibit M1 function by 78c, consequently rescued cartilage from degradation by inflammation. Mechanically, an RNA sequencing analysis revealed that the LFDCS could ameliorate chondrocyte dysfunction by down-regulating PI3K/AKT signaling and inflammation response. LFDCS greatly reduced friction on articular surfaces, suppressed M1-induced inflammation and attenuated chondrocyte dysfunction in OA rats. In conclusion, the bionic bearing-inspired lubricating microspheres characterized by M1-phenotype macrophage-targeted addresses the unfavorable factors of both the physical and physiological microenvironments in macrophage-mediated diseases.

Indexed as

Immunologic FactorsLubricantsMicrospheresOsteoarthritisAnimalsCartilage, ArticularChondrocytesChondroitin SulfatesHydrogelsLubricationMacrophagesMaleMiceRatsRats, Sprague-DawleyRAW 264.7 CellsChondroitin SulfatesHydrogelsImmunologic FactorsLubricantsCartilage adhesionChondroitin sulfateInflammatoryMicrospheresOsteoarthritisSericin methacryloyl

Identifiers

PMID40542398
PMCPMC12180219

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.