SynthesisThe oncologist2025
The prognostic role of Geriatric 8 in patients with cancer: a meta-analysis and systematic review.
Synthesis in The oncologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- The geriatric 8 score as a predictor of postoperative outcomes in elderly patients undergoing esophagectomy.General thoracic and cardiovascular surgery · 2026Article
- Caring for Older Adults with Acute Myeloid Leukemia: Best Practices for Aligning Patient Fitness and Preference with Available Therapies.Drugs & aging · 2026Review
- Geriatric 8 score predicts surgical risk and oncologic outcomes in older patients with upper tract urothelial carcinoma undergoing radical nephroureterectomy.BMC geriatrics · 2026Article
- Personalizing cancer care for older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Article
- Prognostic value of nutritional and functional screening instruments for mortality in patients with hematologic malignancies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- A prospective, multicenter, observational study of trastuzumab deruxtecan in elderly patients with HER2-positive gastric cancer: EN-COURAGE.ESMO gastrointestinal oncology · 2026Article
- The prognostic value of cachexia index in patients with lung cancer treated with immune checkpoint inhibitors: a propensity score matching analysis.Frontiers in nutrition · 2026Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivePrevious studies have reported conflicting results regarding the association between the Geriatric 8 (G-8) geriatric screening tool and prognosis in patients with cancer. This meta-analysis aimed to evaluate the prognostic value of the G-8 score in patients with cancer.
methodsPubMed, Cochrane Library, Embase, and Medline databases were searched to identify trials exploring the association between G-8 score and prognosis in patients with cancer. Meta-analyses of overall survival (OS) and progression-free survival (PFS) between the high and low G-8 scores were performed. The quality of the included studies was assessed using the Quality In Prognosis Studies tool.
resultsA total of 42 studies involving 9053 patients with cancer were included. The prevalence of frailty, evaluated using the G-8 tool across trials, ranged from 27% to 91%. A low G-8 score was associated with poor OS (Hazard ratio [HR] 2.11; 95% CI:1.93-2.31, P <.001) and PFS (HR 1.78, 95% CI,1.55-2.05, P <.001) in patients with cancer. Overall survival were shorter in patients with low G-8 scores than in those with high G-8 scores in digestive system tumors, head and neck cancer, lung cancer, gynecologic tumors, hematologic malignancies, and prostate cancer. The predictive role of the G-8 tool was also confirmed in subgroups with G-8 cutoff values of 9-14. Patients with low G-8 scores had more advanced disease stages and higher ECOG performance status scores.
conclusionsThe prevalence of frailty was high among patients with cancer according to the G-8 geriatric screening tool. Decreased G-8 scores are significantly associated with poor survival in patients with cancer. G-8 is a promising tool for frailty screening.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.