Evidence map›Paper›PMID 40542858›Full record

Observational studyEuropean journal of nuclear medicine and molecular imaging2025

[

B van Leer, M Londema, Ö Kasalak, J H van Snick, M L Duiverman, J C Kuijvenhoven, M D de Kruif, D E Oprea-Lager, K Pabst, M E Hellemons and 7 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. The importance of mechanical forces in chronic respiratory diseases.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  4. EJNMMI research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

B van LeerDepartment of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. b.van.leer@umcg.nl.ORCID 0000-0002-6597-205X
M LondemaDepartment of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Ö KasalakDepartment of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
J H van SnickDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, TA29, PO box: 30001, Groningen, The Netherlands.
M L DuivermanDepartment of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
J C KuijvenhovenDepartment of Pulmonology, Medical Center Leeuwarden, Leeuwarden, The Netherlands.
M D de KruifDepartment of Pulmonology, Zuyderland Medical Center, Heerlen, The Netherlands.
D E Oprea-LagerDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
K PabstDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Essen, Essen, Germany.
M E HellemonsDepartment of Pulmonology, Erasmus Medical Center, Erasmus University Rotterdam, Rotterdam, The Netherlands.
H H BoersmaDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, TA29, PO box: 30001, Groningen, The Netherlands.
M ProkopDepartment of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
M W NijstenDepartment of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
A W J M GlaudemansDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, TA29, PO box: 30001, Groningen, The Netherlands.
J Pillay *Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
R H J A Slart *Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, TA29, PO box: 30001, Groningen, The Netherlands.
COVID-CLIMATE consortium

Funding

ZonMw 50-56300-98-2104
6 · The paper itself

Abstract

purposePost-acute sequelae of COVID-19 (PASC) has emerged as a major healthcare problem. A comprehensive mechanism of disease remains to be elucidated. In this study we aimed to explore pulmonary and muscle fibroblast activation protein (FAP) activity in former critical COVID-19 patients with persistent dyspnea, using [

methodsIn this single center prospective observational study we included former critical COVID-19 patients reporting complaints of dyspnea > 3 months after hospital discharge. A [

resultsEighteen PASC patients and 15 controls (median age 59 and 63 years and BMI of 34.6 and 25.2 kg/m

conclusion[

Indexed as

COVID-19LungMembrane ProteinsPatient DischargePositron Emission Tomography Computed TomographySerine EndopeptidasesAgedEndopeptidasesFemaleFibroblast Activation Protein AlphaGallium RadioisotopesHumansMaleMiddle AgedProspective StudiesQuinolines68Ga-FAPIEndopeptidasesFibroblast Activation Protein AlphaGallium RadioisotopesMembrane ProteinsQuinolinesSerine EndopeptidasesCritically illFAPI PET/CTLong COVIDMusclesPost-acute sequalae of COVID-19Respiratory

Identifiers

PMID40542858
PMCPMC12660325

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.