Low-intensity therapeutic ultrasound effects on intracellular sodium and reactive oxygen species in ex vivo human islets for control of insulin release.

Andrew W Chen, Aleksandar Jeremic, Vesna Zderic

Abstract read

In one paragraph

Article in Ultrasonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrew W ChenDepartment of Biomedical Engineering, The George Washington University, Washington DC, 800 22(nd) St NW Suite 5000, Washington, DC 20052, United States.

Aleksandar JeremicDepartment of Biological Sciences, The George Washington University, Washington DC, 800 22(nd) St. NW Suite 6000, Washington, DC 20052, United States.

Vesna ZdericDepartment of Biomedical Engineering, The George Washington University, Washington DC, 800 22(nd) St NW Suite 5000, Washington, DC 20052, United States. Electronic address: zderic@gwu.edu.

Funding

Therapeutic ultrasound for stimulation of insulin releaseR01EB027648 · NIBIB · GEORGE WASHINGTON UNIVERSITY · PI ZDERIC, VESNA · 2020 to 2023

$2.0M

NIBIB NIH HHS R01 EB027648

6 · The paper itself

Abstract

Ultrasound has shown potential to non-invasively stimulate insulin release from pancreatic β-cells, but the underlying mechanisms remain poorly understood. Prior studies have suggested that mechanical effects from ultrasound, such as membrane deformation and cavitation, may play a role in modulating ion channel activity and insulin secretion. However, direct observations of intracellular signaling responses in human islets during ultrasound application are limited. In this work we investigate the effects of ultrasound on human islets in vitro using confocal fluorescence microscopy and enzyme-linked immunosorbent assay (ELISA) to measure intracellular sodium and reactive oxygen species (ROS). Human islets obtained through the NIDDK Integrated Islet Distribution Program (IIDP) were treated with ultrasound, and high glucose. Ultrasound was applied using an 800 kHz unfocused transducer for 3 min at 0.5 W/cm

Indexed as

InsulinIslets of LangerhansReactive Oxygen SpeciesSodiumUltrasonic TherapyGlucoseHumansInsulin SecretionIn Vitro TechniquesMicroscopy, ConfocalGlucoseInsulinReactive Oxygen SpeciesSodiumFluorescence imagingHuman isletsTherapeutic ultrasoundType 2 diabetes

Identifiers

PMID40543425

DOI10.1016/j.ultras.2025.107737

PMCPMC12259349

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.