ReviewAntiviral research2025
Host-directed approaches in the pursuit of a cure for HIV.
Review in Antiviral research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Antiviral and anti-inflammatory effects of Cannabidiol in HIV/SIV infection.Brain, behavior, and immunity · 2026Article
- Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy.Nature microbiology · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The success of antiretroviral therapy (ART) for people with HIV has been a result of direct acting antiviral small molecules that target key components of the viral life cycle, however ART must be taken life long and there is no cure. The major barrier to a cure for HIV is the persistence of a long lived and proliferating reservoir of latently infected cells that persist on ART. Cure strategies for HIV currently target host proteins to either reduce the size of the reservoir or enhance HIV-specific immunity. A major challenge of targeting a host protein is the lack of specificity for HIV and therefore increased risk of adverse events. However, cure strategies are designed to be time limited, as opposed to ART which is lifelong. Here we review host-directed cure strategies that modulate HIV transcription and infection, enhance cell death and/or increase HIV-specific immune control. Ultimately a cure strategy will require a combination of these interventions.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.