Evidence map›Paper›PMID 40544135›Full record

ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2025

Intersection of H

Priyanka Soni, Shravan Paswan, Bindu D Paul, Bobby Thomas

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Review
  7. Review
  8. Gasotransmitter signaling in the brain: New frontiers for therapeutics.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Priyanka SoniDarby Children's Research Institute, Medical University of South Carolina, Charleston, SC, USA; Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
Shravan PaswanDarby Children's Research Institute, Medical University of South Carolina, Charleston, SC, USA; Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
Bindu D PaulDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Lieber Institute for Brain Development, Baltimore, MD, USA. Electronic address: bpaul8@jhmi.edu.
Bobby ThomasDarby Children's Research Institute, Medical University of South Carolina, Charleston, SC, USA; Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA; Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; Department of Drug Discovery, Medical University of South Carolina, Charleston, SC, USA. Electronic address: thomasbo@musc.edu.

Funding

Molecular Mechanisms of Oxidation Resistance 1 in Parkinson's disease and Lewy Body DementiaR01NS133688 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Bobby Thomas · 2023 to 2026
$2.3M
Role of Bach-1-Mediated Transcriptional Regulation in NeuroprotectionR01NS101967 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI THOMAS, BOBBY · 2017 to 2021
$1.9M
NINDS NIH HHS R01 NS101967NINDS NIH HHS R01 NS133688
6 · The paper itself

Abstract

Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), represent a significant global health burden due to their progressive and debilitating nature. While the etiology of these disorders is multifaceted, oxidative stress, resulting from an imbalance between the generation of reactive oxygen species (ROS) and neuronal antioxidant stress responses, has emerged as a pivotal factor in their pathogenesis. Amongst the cellular defense mechanisms counteracting oxidative stress, signaling cascades regulated by the nuclear factor erythroid 2-related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1) signaling axis, play a crucial role. Nrf2 signaling is modulated at multiple levels and regulates redox homeostasis and other cellular processes such as expression of neuroprotective genes, resolution of neuroinflammation, stimulating mitochondrial bioenergetics, facilitating cellular repair, and proteostasis. In recent years, the gaseous molecule or gasotransmitter, hydrogen sulfide (H

Indexed as

Hydrogen SulfideNeurodegenerative DiseasesNF-E2-Related Factor 2Signal TransductionAnimalsHumansKelch-Like ECH-Associated Protein 1Oxidative StressHydrogen SulfideKelch-Like ECH-Associated Protein 1NFE2L2 protein, humanNF-E2-Related Factor 2Alzheimer's diseaseGasotransmittersHuntington's diseaseNeurodegenerative diseasesNrf2-Keap1 signalingParkinson's disease

Identifiers

PMID40544135
PMCPMC12664487

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.