ReviewDigestive diseases and sciences2025
MicroRNAs as Key Modulators of Intestinal Barrier Function: Pattern Recognition Receptors, Epithelial Junctional Complexes, and Therapeutic Approaches.
Review in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities.MedComm · 2026Review
- The ubiquitin-editing enzyme A20 (TNFAIP3): mechanisms of activation, biological function, diseases and therapeutic targets.Molecular biomedicine · 2026Review
- The role of the gut microbiota in radiation enteritis: from mechanistic insights to therapeutic applications.Communications biology · 2026Review
- Repurposing alogliptin for ulcerative colitis: involvement of MicroRNAs, anti-inflammatory, and barrier-restoring mechanisms.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Small but Powerful: MicroRNAs Link Pattern Receptors to Junctional Complexes in Intestinal Barrier Regulation.Digestive diseases and sciences · 2026Article
- MicroRNAs orchestrating host and vector-borne protozoan interactions: bridging immune modulation and cross-species communication.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis review aims to investigate the regulatory role of microRNAs (miRNAs) in intestinal barrier function, with a focus on their interaction with pattern recognition receptors (PRRs) such as Toll-like receptors (TLR2, TLR4, TLR5) and nucleotide-binding oligomerization domain (NOD) receptors. Additionally, the review explores how miRNAs influence epithelial junctional complexes-including tight junctions, adherens junctions, and desmosomes-and their implications in inflammatory bowel diseases (IBD).
methodsA comprehensive literature review was conducted to examine recent studies focusing on miRNA-mediated modulation of signaling pathways related to PRRs and junctional complexes. Particular attention was given to the expression and regulation of key junctional complexes such as claudin, occludin, and zonula occludens, and their relationship with epithelial homeostasis.
resultsEmerging evidence demonstrates that miRNAs modulate both inflammatory signaling and structural junctional integrity. Dysregulated expression of specific miRNAs is associated with impaired barrier function and increased intestinal permeability, contributing to the pathogenesis of IBD. Moreover, experimental data suggest that miRNA mimics and antagomiRs may help restore epithelial barrier integrity and reduce inflammation.
conclusionMiRNAs play a central role in maintaining intestinal barrier homeostasis by targeting PRRs and junctional complexes. Their ability to modulate inflammation and barrier function highlights their potential as therapeutic targets. miRNA-based strategies may offer novel, targeted treatments for IBD and other intestinal disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.