ArticleMicrobial cell factories2025
Development of a lysine biosensor for the dynamic regulation of cadaverine biosynthesis in E. coli.
Article in Microbial cell factories, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Construction of a pathway-independent three-module self-induced regulatory system and its application in 3-hydroxypropionic acid production.Engineering microbiology · 2026Article
- Biosensor-driven evolution and metabolic engineering of an Escherichia coli cell factory for L-tryptophan production.Microbial cell factories · 2026Article
- Programming Next-Generation Synthetic Biosensors by Genetic Circuit Design.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
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Authors and funding
7 authors.
Funding
Abstract
backgroundAs one of the most promising monomers of biobased polyamides, cadaverine has wide industrial application prospects. However, in microbial cadaverine fermentation with glucose as the sole carbon source, the impaired coordination between precursor (lysine) utilization and cytotoxic cadaverine accumulation has been identified as the primary bottleneck limiting high-yield biosynthesis. Here, we developed a lysine biosensor in Escherichia coli to dynamically regulate cadaverine biosynthesis.
resultsIn this study, we developed a lysine biosensor based on the lysine transporter protein LysP, the transcription activator CadC, and the GFPuv gene under the control of the P
conclusionThis is the first report in which a lysine biosensor constructed in E. coli could dynamically regulate cadaverine synthesis to improve its yield and biomass. This strategy provides new insights into the metabolic engineering of lysine and its derivatives in E. coli.
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