GIP/GLP-1 & amylin agonists × body weight & composition

TrialThe New England journal of medicine2025

Cagrilintide-Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes.

Melanie J Davies et al.PubMed ↗Publisher ↗

  • Cagrilintide-semaglutide (2.4 mg each)looks good hereLower body weight from baseline to week 68.Randomised, large.

What the trial testedrandomised · 1,206 people · 2025

Randomised vs placebo

Lowered body weight from baseline to week 68

−10.4percentage points−11.2 to −9.50

cagrilintide-semaglutide (2.4 mg each) vs placebo

As reported

difference −10.4 percentage points, 95% CI −11.2 to −9.50 · the paper's word: mean change in body weight from baseline to week 68

Who was studied, and how

1,206people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

cagrilintide-semaglutide (2.4 mg each)
placebo

Lowered body weight from baseline to week 68−10.4

randomised

the abstract, start to end

the placebo group (estimated difference, -10.4 percentage points; 95%

← favours treatmentfavours comparator →
could be chance
Mean change in body weight from baseline to week 68cagrilintide-semaglutide (2.4 mg each) vs placebo
−10.4−11.2 to −9.50
GLP-1 receptor agonistsGIP/GLP-1 & amylin agonistsBody weight & composition

GIP/GLP-1 & amylin agonists × body weight & compositionhelps?replicated

unlikelylikely
1.001.00 without it

GLP-1 receptor agonists × body weight & compositionhelps?replicated

unlikelylikely
0.900.90 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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55 papers cite it

2025
2026
this paperpooled ittrialcites it

The trial

Full record →Abstract, authors, funding and every citing paper · PMID 40544432