Trial reportAmerican heart journal2025
A mobile relational agent to enhance atrial fibrillation self-care: Primary and secondary outcomes of a randomized controlled trial.
Trial report in American heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04075994 (A Mobile Relational Agent to Enhance Atrial Fibrillation Self-care), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Mobile Relational Agent to Enhance Atrial Fibrillation Self-care
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of Digital Health Interventions to Improve Self-Care in Patients With Chronic Diseases: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2026Pooled it
- Trial
- Effect of Health Literacy on use of a Virtual Coach to Promote Home Blood Pressure Monitoring.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Promoting Family Communication for Cascade Cancer Genetic Testing With Relational Agent Role-Play: Quasi-Experimental Study.JMIR formative research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundAtrial fibrillation (AF) requires long-term adherence to oral anticoagulation and self-care.
methodsWe conducted a randomized controlled trial of a smartphone-based relational agent and heart rhythm monitor with the primary outcome of anticoagulation adherence and secondary outcomes of quality of life (QOL) and health care utilization. The trial enrolled individuals with Atrial fibrillation (AF) taking anticoagulation. Intervention participants received a smartphone-based relational agent for disease education, adherence monitoring, and self-care, and a heart rate and rhythm monitor. Attention control participants received a smartphone health education application and the same heart monitor. Participants had baseline and 4-, 8-, and 12-month visits. The primary outcome was 12-month proportion of days covered (PDC) ascertained with pharmacy claims.
resultsFrom January, 2020 to April, 2022, the trial enrolled 243 participants (age 70.8 ± 9.8 years; 64.2% female; 30.5% Black race). The adjusted mean PDC at 12 months in the intervention arm was 0.88 (95% Confidence Interval [CI], 0.84-0.93) and in the attention control 0.85 (95% CI, 0.81-0.90) with no difference in odds of PDC ≥ 0.80 in intervention compared to the control (Odds Ratio, 1.26 [95% CI, 0.66-2.38]). Self-reported nonadherence and QOL did not differ by study arm. The event rates for health care utilization were significantly less for intervention than attention control participants as measured by emergency room visits and hospitalizations (P < .001) and number of days hospitalized (P = .004).
conclusionThe smartphone-based relational agent intervention did not achieve its primary endpoint of increased anticoagulation adherence but did yield decreased health care utilization.
trial registrationClinicalTrials.gov Identifier: NCT04075994.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.