Evidence map›Paper›PMID 40545235›Full record

ArticleJournal of advanced research2026

The novel synbiotic (Lactiplantibacillus plantarum and galacto-oligosaccharides) ameliorates obesity-related metabolic dysfunction: Arginine as a key mediator signaling molecule.

Renjie Shi, Jiangpeng Wei, Jin Ye, Xin Song, Xin Yang, Yi Zhang, Songling Liu, Junli Ren, Danna Wang, Zhenting Zhao and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Characterization of a β-Galactosidase fromMolecules (Basel, Switzerland) · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Renjie ShiCollege of Food Science and Engineering, Northwest A&F University, Yangling 712100, China; School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, China.
Jiangpeng WeiThe First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China.
Jin YeCollege of Food Science and Engineering, Northwest A&F University, Yangling 712100, China; Institute of Biology, Gansu Academy of Sciences, Lanzhou 730000, China.
Xin SongUniversity of Shanghai for Science and Technology, Shanghai 200093, China.
Xin YangDepartment of Food Science and Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China; Section of Endocrinology, Internal Medicine, School of Medicine, Yale University, New Haven, CT, United States.
Yi ZhangSchool of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710126, China.
Songling LiuBGI Group, BGI-Shenzhen, Shenzhen 518120, China.
Junli RenBGI Group, BGI-Shenzhen, Shenzhen 518120, China.
Danna WangCollege of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
Zhenting ZhaoCollege of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
Zhigang LiuCollege of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
Yutang WangCollege of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
Beita ZhaoCollege of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
Chunxia XiaoCollege of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
Xiaoshuang DaiBGI Group, BGI-Shenzhen, Shenzhen 518120, China. Electronic address: daixiaoshuang@xbiome.com.
Lianzhong AiUniversity of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address: ailianzhong@usst.edu.cn.
Xuebo LiuCollege of Food Science and Engineering, Northwest A&F University, Yangling 712100, China. Electronic address: xuebofood@nwafu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to develop a novel synbiotic composed of Lactiplantibacillus plantarum LLY-606 and galacto-oligosaccharides (GOS) to improve lipid metabolism in obesity.

designThrough genome-wide analysis using COG and CAZy databases, we identified GOS as a specific growth substrate for Lactiplantibacillus plantarum LLY-606. The efficacy of this synbiotic (LP-GOS) was evaluated in both obese individuals and high-fat diet-induced obese mice.

resultsLP-GOS supplementation reduced visceral fat and waist circumference in humans and attenuated obesity in mice. It also improved gut microbiota composition and increased serum arginine levels. Metabolomic and microbiota analyses suggested that enhanced arginine production plays a key role. This was further confirmed by arginine synthesis inhibition, antibiotic treatment, and CRISPR-Cas9-mediated knockout of the Ass1 gene in Lactiplantibacillus plantarum LLY-606. These interventions demonstrated that LP-GOS improves lipid metabolism through arginine-mediated activation of the AMPK pathway.

conclusionsLP-GOS effectively alleviates obesity-associated lipid metabolism disorders by enhancing arginine production and activating the AMPK signaling pathway.

Indexed as

ArginineObesityOligosaccharidesSynbioticsAnimalsDiet, High-FatFemaleGastrointestinal MicrobiomeHumansLactiplantibacillus plantarumLipid MetabolismMaleMiceMice, Inbred C57BLMiddle AgedSignal TransductionArginineOligosaccharidesArginineGut microbiotaLactiplantibacillus plantarumObesitySynbiotic

Identifiers

PMID40545235
PMCPMC12957849

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.