Evidence map›Paper›PMID 40545266›Full record

SynthesisObesity reviews : an official journal of the International Association for the Study of Obesity2025

Psychiatric and Cognitive Functioning After Metabolic and Bariatric Surgery: A Systematic Review and Meta-Analysis.

Emma A van Reekum, Michael Darcy, Jaslyn Drage, Joshua Xu, Kimberly Ng, Benjamin Forestell, Nancy Santesso, Raed A Joundi, Jorge Wong, Aristithes Doumouras and 3 more

Registry-linked trialAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Obesity reviews : an official journal of the International Association for the Study of Obesity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07780058 (Psychological Impact of Bariatric Surgery in Patients With Morbid Obesity), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07780058 recruitingnot on this map

Psychological Impact of Bariatric Surgery in Patients With Morbid Obesity: a Longitudinal Study Protocol

Typeobservational_patient_registrySponsorUniversity of AlicanteRan2025 to 2028Enrolled70ConditionsObesity
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Psychiatric and Cognitive Functioning After Metabolic and Bariatric Surgery: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Pooled it
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emma A van ReekumDepartment of Psychiatry and Behavioural Neurosciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-3823-8394
Michael DarcyDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Jaslyn DrageDepartment of Psychiatry and Behavioural Neurosciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Joshua XuDepartment of Surgery, University of Calgary, Calgary, Alberta, Canada.
Kimberly NgDepartment of Psychiatry and Behavioural Neurosciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Benjamin ForestellEmergency Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Nancy SantessoDepartment of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-0550-4585
Raed A JoundiPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.
Jorge WongPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.
Aristithes DoumourasDepartment of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Valerie H TaylorDepartment of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
Salim YusufDepartment of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Ryan Van LieshoutDepartment of Psychiatry and Behavioural Neurosciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo systematically review and meta-analyze psychiatric and cognitive outcomes following metabolic and bariatric surgery (MBS). [Correction added on 1 July 2025, after first online publication: The objective statement has been updated for clarity.]

methodsSix databases were searched. Randomized controlled trials (RCTs) and nonrandomized studies (NRS) of people with obesity comparing MBS with any nonsurgical intervention or control condition were included. Main outcomes included symptoms of depression, anxiety, and non-normative eating, substance use disorder diagnosis, suicide death, and cognitive performance in attention, memory, and executive function. Evidence certainty was assessed with GRADE. Heterogeneity was explored with subgroup analyses of ≤ 2 years vs. > 2 years post-intervention.

resultsThere were 79 studies (75 NRS and 4 RCTs) found, including 732,149 people with obesity who underwent MBS, and 7,670,770 who did not. Among RCTs, MBS may improve depressive symptoms (standardized mean difference [SMD] = -0.40, 95% CI -1.04, 0.24; very low certainty). Among NRS, there was low to very low certainty that MBS may improve depressive (SMD = 0.56, 95% CI -0.87, -0.26), anxiety (SMD = -0.60, 95% CI -1.00, -0.19), and non-normative eating symptoms (SMD = -0.75, 95% CI -0.97, -0.53) and cognitive performance in attention (SMD = -0.72, 95% CI -1.61, 0.17), but not executive function or memory. MBS may slightly increase suicide deaths (1/1000 more people, 95% CI 0 fewer to 3 more; very low certainty) and substance use disorders (4/100 more, 95% CI from 1 to 9 more; low certainty) > 2-years post-surgery.

conclusionsCompared to nonsurgical conditions, MBS may improve depression, anxiety, non-normative eating, and attention, but slightly increase suicides and substance use disorders. There was low to very low certainty in most outcomes, therefore additionalhigh-quality studies are needed to strengthen the evidence base.

Indexed as

Bariatric SurgeryCognitionObesityAnxietyDepressionHumansRandomized Controlled Trials as Topiccognitive functionmental healthmetabolic and bariatric surgeryobesity

Identifiers

PMID40545266
PMCPMC12531740

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.