ArticleRMD open2025
Different rheumatoid factor binding patterns distinguish between Sjögren's disease with or without associated RA.
Article in RMD open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRheumatoid arthritis (RA) and Sjögren's disease (SjD) are two rheumatic autoimmune diseases that commonly co-occur. Besides some overlap in clinical presentation, the two diseases share the frequent occurrence of rheumatoid factors (RF); autoantibodies targeting the constant region of IgG (IgG-Fc). We previously demonstrated that RFs of patients with RA or SjD have distinct reactivity profiles towards various epitopes on IgG-Fc, prompting the question of whether binding patterns in patients with RA-associated SjD (SjD-RA) would reflect either disease or a combination thereof.
methodsWe determined IgM- and IgA-RF levels against a selected set of RF targets that were developed to map preferential RF binding to specific epitopes. We assessed binding patterns among 14 patients with SjD-RA and compared these to patterns found among 28 patients with early RA and 152 patients with SjD.
resultsBoth IgM-RF and IgA-RF profiles of SjD-RA patients closely resemble those of RA patients and are distinctly different from those found among SjD patients. Furthermore, the presence and binding pattern of RF seems to be inherently linked to the presence of anti-SSA/Ro antibodies in patients with SjD.
conclusionsAnalysing RF binding patterns could help to distinguish SjD, SjD-RA, RA and contributes to a better understanding of the underlying immunological processes in a complex multidisorder setting.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.