Evidence map›Paper›PMID 40545300›Full record

Observational studyBMJ open2025

Associations of sleep characteristics with all-cause, cardiovascular and non-cardiovascular mortality among rural Chinese older adults: a cohort study.

Jie Lu, Rui Liu, Jiafeng Wang, Keke Liu, Juan Ren, Tong Zhao, Yifei Ren, Ming Mao, Yajun Liang, Shi Tang and 2 more

Abstract readObservational Study
In one paragraph

Observational study in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jie LuDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Rui LiuDepartment of Ultrasound, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Jiafeng WangDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Keke LiuDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Juan RenDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Tong ZhaoDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Yifei RenDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Ming MaoDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Yajun LiangDepartment of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Shi TangDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China tangshi1989@163.com du-yifeng@hotmail.com.ORCID http://orcid.org/0000-0003-4241-6058
Yifeng DuDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China tangshi1989@163.com du-yifeng@hotmail.com.
Chengxuan QiuDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesThe longitudinal associations of sleep timing and time in bed (TIB) with all-cause, cardiovascular and non-cardiovascular mortality are unclear in Chinese rural populations.

methodsThis population-based cohort study included 2468 participants who were aged ≥60 years and residing in rural communities in western Shandong Province. Sleep timing and TIB were assessed using standard questionnaires at baseline in 2014. Mid-sleep time was defined as the halfway point between the bedtime and wake-up time. Vital status until December 2022 and causes of death for all participants were ascertained via death registry plus interviews with informants (eg, family members or village doctors). Data were analysed using restricted cubic splines (RCS) and Cox proportional-hazards models.

resultsDuring the mean follow-up of 7.36 (SD 2.03) years, 657 participants died. The RCS analysis showed non-linear relationships of sleep duration and mid-sleep time at baseline with all-cause and cardiovascular mortality. Specifically, when baseline sleep characteristics were categorised into tertiles, the multivariable-adjusted HR for all-cause mortality was higher for long sleep duration (>8 vs 7-8 hours; HR 1.27; 95% CI 1.06 to 1.53), long TIB (>9 vs <8 hours; 1.63; 1.27 to 2.08), early bedtime (before 21:00 vs 22:00 or later; 1.58; 1.00 to 2.49) and early mid-sleep time (before 01:00 vs 01:00 -01:30; 1.45; 1.20 to 1.76). Long TIB was associated with a multivariable-adjusted HR of 1.61 (1.15 to 2.27) for cardiovascular mortality and 1.64 (1.09 to 2.47) for non-cardiovascular mortality.

conclusionsLong sleep duration and early sleep timing might be associated with increased risk of all-cause and cardiovascular mortality in rural Chinese older adults. In addition, long TIB might be linked to an increased risk of all-cause, cardiovascular and non-cardiovascular mortality.

Indexed as

Cardiovascular DiseasesRural PopulationSleepAgedAged, 80 and overCause of DeathChinaCohort StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedProportional Hazards ModelsRisk FactorsTime FactorsAgedCardiovascular DiseaseMortality

Identifiers

PMID40545300
PMCPMC12184377

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.