Trial reportLasers in medical science2025
Effect Of Photobiomodulation (Low-Level Laser Therapy) In Patients With Knee Osteoarthritis: A Randomized Controlled Trial.
Trial report in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate the effects of photobiomodulation (low-level laser therapy) on patients with symptomatic knee osteoarthritis through a double-blind, randomized clinical trial conducted in accordance with the CONSORT guidelines for non-pharmacological interventions. The initial sample included 73 participants of both sexes; however, 8 individuals withdrew, leaving 65 for final analysis. Participants were randomly assigned to one of three groups: photobiomodulation (PBM), sham (placebo), or control (no intervention). In the PBM group, 83% were female and 17% male; the sham and control groups had 85% female and 15% male. The PBM group received treatment following WALT recommendations, using a 790 nm wavelength laser delivering 4 J per point, applied to nine specific areas of the knee. Significant reductions in pain (p < 0.05) were observed in the PBM group after treatment, compared to both the placebo and control groups. WOMAC scores showed significant improvements in pain, stiffness, and functional limitations within the PBM group (pre- vs. post-treatment) (p < 0.05), while no significant changes were found in the sham or control groups (p > 0.05). These findings demonstrate that photobiomodulation (790 nm, 120 mW, 4 J/point) is effective in reducing pain (VAS), improving daily function and quality of life (KOOS), and enhancing clinical outcomes in patients with knee osteoarthritis, specifically when compared to sham and control conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.