ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
The association between poor sleep health and Alzheimer's disease structural neuroimaging biomarkers.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Accelerometer-derived real-world sleep stages and risk of incident diseases: A UK Biobank cohort study and phenome-wide association analysis.PLoS medicine · 2026Article
- Current Strategies for Healthy Aging: The Interplay Between Nutrition, Metabolism, and Exercise.Cureus · 2025Review
- Advances of therapeutic strategies for Alzheimer's disease.Journal of neurology · 2025Review
- The association between poor sleep health and Alzheimer's disease structural neuroimaging biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
introductionPoor sleep may be a risk factor for neurodegeneration and Alzheimer's disease (AD). Few studies have examined objectively measured sleep with structural neuroimaging measures.
methodsVanderbilt Memory and Aging Project participants (N = 407; median age: 70 years) wore ActiGraph accelerometers for 10 days to estimate sleep regularity, timing, efficiency, duration, wake-after-sleep onset, and awakening length. Volume in brain regions of interest (ROIs) and AD signatures were quantified using 3T brain magnetic resonance imaging (MRI). Cross-sectional linear regression models were adjusted for sociodemographic and lifestyle factors, depression, cognitive status, and cardiovascular risk. ROI and McEvoy models were adjusted for total intracranial volume.
resultsGreater sleep irregularity (β DISCUSSION: More irregular and fragmented sleep was associated with smaller volume in ROIs vulnerable to AD, indicating a potential link between poor sleep and neurodegeneration. HIGHLIGHTS: Associations between sleep and brain health are poorly understood. Gray matter atrophy by irregular sleep may imply Alzheimer's disease (AD) decline. Increased sleep irregularity is associated with smaller brain region volume. Sleep disruption, estimated by awakening length, is linked to AD-related brain volume.
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Registered trials
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