ArticleCancer control : journal of the Moffitt Cancer Center
aMMP-8 and MMP-9: Potential Biomarkers for periodontitis Progression in Patients Receiving Radiotherapy for Head and Neck Carcinoma.
Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Association and predictive value of C-reactive protein, fibrinogen and periodontal indices in periodontitis severity : a cross-sectional study.Clinical oral investigations · 2026Article
- Red-complex bacteria: immunological background leading to the development of head and neck cancers.Frontiers in immunology · 2026Review
- Point-of-Care Biomarker Monitoring of Treatment Efficacy: Changes in Mouthrinse Active Matrix Metalloproteinase-8 (aMMP-8) Concentrations Following Periodontal Anti-Infective Treatment.International journal of dentistry · 2026Article
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Authors and funding
10 authors.
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Abstract
IntroductionMatrix metalloproteinases (MMP)-8 and -9 are regarded as biomarkers for periodontitis. The impact of head and neck carcinoma (HNC) radiotherapy (RT) on these biomarkers remains largely unexplored. This study aims to evaluate the impact of HNC RT on the proteases from host and bacteria, and their associations with the progression of periodontitis.MethodsTwenty-one patients with HNC receiving RT were included in this study. Mouthrinse samples were collected before RT (T0) and at the end of RT (T1). Periodontal examinations were conducted at T0 and one month after RT (T2). Samples were analyzed using a point-of-care kit for active (a) MMP-8, and ELISA for total (t) MMP-8, MMP-9, and interleukin (IL)-6 levels. Molecular forms of MMP-9 were assessed by gelatinolytic zymography. The activity levels of bacterial proteases, gingipain from
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