Evidence map›Paper›PMID 40545694›Full record

ArticleBritish journal of haematology2025

Lamotrigine and anti-seizure medications in HLH: A systematic review.

Yaswanta K Gummadi, Ashley E Sutherland, Kristin M Ikeda, Lori Connors, Luke Y C Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Bipolar disorder in oncology: Considerations for the psychiatrist.Journal of mood and anxiety disorders · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yaswanta K GummadiDepartment of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.ORCID https://orcid.org/0000-0003-3530-4832
Ashley E SutherlandDivision of Clinical Dermatology and Cutaneous Science, Dalhousie University, Halifax, Nova Scotia, Canada.ORCID https://orcid.org/0009-0005-0734-1769
Kristin M IkedaDivision of Neurology, Dalhousie University, Halifax, Nova Scotia, Canada.
Lori ConnorsDivision of General Internal Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Luke Y C ChenDivision of Hematology, Dalhousie University, Halifax, Nova Scotia, Canada.ORCID https://orcid.org/0000-0002-9551-2951

Funding

Hsu & Taylor Family through the VGH & UBC Hospital Foundation
6 · The paper itself

Abstract

Lamotrigine and other anti-seizure medications have been reported to cause both haemophagocytic lympho-histiocytosis (HLH) and drug-induced hypersensitivity syndrome (DIHS). HLH and DIHS have many characteristic clinical, laboratory, pathological findings and underlying mechanisms; we identified significant clinical overlap between these two syndromes in our systematic review. Of note, the presence of haemophagocytosis on bone marrow biopsy, while supportive, is not exclusive to or synonymous with a diagnosis of HLH.

Identifiers

PMID40545694
PMCPMC12378906

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.