ArticleObesity (Silver Spring, Md.)2025
Fat taste sensitivity in women with obesity: transcriptomic analysis of fungiform papillae before and after bariatric surgery.
Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02497274 (Obesity and Lipids), which is not on this map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Obesity and Lipids: a Matter of Taste? Impact of Bariatric Surgery on Taste Receptors
Who cites it
2 citing papers in PubMed.
- Fat taste sensitivity in women with obesity: transcriptomic analysis of fungiform papillae before and after bariatric surgery.Obesity (Silver Spring, Md.) · 2025Article
- Inflammation in Obstructive Sleep Apnea: A Global Bibliometric Perspective.Nature and science of sleep · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
objectiveFat taste sensitivity has been implicated in long-term weight loss after bariatric surgery. Unexpectedly, improvement of orosensory fat acuity was not systematic in operated patients.
methodsObesity-induced alterations of gene expression in gustatory papillae having been recently reported, we have explored the fungiform transcriptomic activity in the bariatric surgery context. Fat taste detection thresholds (three-alternative ascending forced-choice tests) alongside transcriptomic profiling of freshly isolated fungiform papillae were assessed in women with severe obesity before and 6 months after sleeve gastrectomy.
resultsAccording to evolution of post surgery detection thresholds, lipid-improved and -unimproved subgroups were identified, despite similar initial anthropometric parameters. Lower weight loss and higher plasma fasting insulin, C-reactive protein, and fibrinogen levels distinguished lipid-unimproved patients. This subgroup also overexpressed genes involved in inflammation and apoptosis, with certain ones being positively correlated with high lipid detection thresholds (low sensitivity), whereas the key gene of taste bud cell signaling, TRPM5, was down-expressed. In lipid-improved patients, genes implicated in cell renewal, neuronal function, and receptor recycling were upregulated and associated with better lipid detection efficiency. Pathway enrichment identified immune and anti-inflammatory activities in lipid-unimproved and -improved groups, respectively.
conclusionsThese findings collectively suggest that changes in gene expression within gustatory papillae contribute to fat taste sensitivity after sleeve gastrectomy.
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