Evidence map›Paper›PMID 40546314›Full record

ArticleMolecular therapy. Oncology2025

Oncolytic adeno-immunotherapy improves allogeneic adoptive HER2.CAR-NK function against pancreatic ductal adenocarcinoma.

Greyson Biegert, Amanda Rosewell Shaw, Daisuke Morita, Caroline Porter, Ryu Matsumoto, Lisa Jatta, Noah Crooks, Mae Woods, Qizhi Cathy Yao, Robin Parihar and 1 more

Abstract read
In one paragraph

Article in Molecular therapy. Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
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  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Greyson BiegertDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.
Amanda Rosewell ShawDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.
Daisuke MoritaDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.
Caroline PorterDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.
Ryu MatsumotoDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.
Lisa JattaDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.
Noah CrooksDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.
Mae WoodsDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.
Qizhi Cathy YaoMichael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
Robin PariharCenter for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston Methodist Hospital, Houston, TX, USA.
Masataka SuzukiDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.

Funding

Training In Cell and Gene TherapyT32HL092332 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, Bruno Di Stefano · 2008 to 2026
$6.9M
CSRD VA I01 CX001822NHLBI NIH HHS T32 HL092332
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) responds poorly to conventional treatments and immunotherapy. We previously developed a binary oncolytic/helper-dependent adenovirus system (CAd

Indexed as

CAR-NK cellhumanized mouse modelMT: Regular Issueoncolytic viro-immuno therapypancreatic ductal adenocarcinomaPDX model

Identifiers

PMID40546314
PMCPMC12179663

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.