ReviewJournal of pain research2025
Efficacy and Temporal Dynamics of Genicular Nerve Block in Primary and Secondary Knee Osteoarthritis for Pain and Function: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Review in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Ultrasound-Guided Genicular Nerve Block: Novel Clinical Role for Postoperative Knee Replacement Surgery Pain Management.Current pain and headache reports · 2026Review
- Ultrasound-guided peripheral nerve blocks for osteoarthritis pain management: a review of the genicular, suprascapular, PENG and deep peroneal nerve blocks.Frontiers in medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Genicular nerve block (GNB) has emerged as a promising intervention for knee osteoarthritis (KOA), yet its comparative efficacy remains incompletely understood. The purpose of this review was to assess the effectiveness of GNB in reducing pain and improving function for primary or secondary KOA. Methods: We conducted systematic searches of PubMed, Web of Science, and Embase up to October 9, 2024, for randomized controlled trials comparing GNB with other therapies. The data were analyzed using Review Manager (RevMan) 5.4, and study quality was assessed using the Cochrane risk of bias tool. Results: This study included six RCTs involving a total of 420 participants. Results revealed that GNB significantly reduced pain (SMD = 1.00, 95% CI: 0.48-1.52, p=0.0002) and improved function (SMD = 1.07, 95% CI: 0.37-1.77, p=0.003) compared to other interventions. Subgroup analyses showed that GNB provided better pain relief at 2 weeks (SMD=1.21; 95% CI: 0.09-2.33; P=0.03) and greater functional improvement at 12 weeks (SMD=1.13; 95% CI: 0.10-2.16; P=0.03). Conclusion: This review suggested GNB as an effective intervention for KOA management, with distinct temporal patterns for pain relief and functional improvement.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.