ArticleiScience2025
Distinct functions of PAXX and MRI during chromosomal end joining.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- No Time to Fold: Intrinsically Disordered Microproteins in Action.Biochemistry · 2026Review
- DNA-damage dependent isoform switching modulates RIF1 DNA repair complex assembly and phase separation.The Journal of biological chemistry · 2025Article
- 53BP1-RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes.Nature communications · 2025Article
- Interactome screening implicates BAG6 as a suppressor of UBQLN2 misfolding in ALS/FTD.Frontiers in molecular neuroscience · 2025Article
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5 authors.
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Abstract
A key step of canonical-nonhomologous end joining is synapsis of DNA double-strand break (DSB) ends, which appears to be mediated by both the DNA-PKcs dimer and XLF homodimer. We have examined this process by monitoring end joining (EJ) of blunt Cas9 DSBs, focusing on the Ku-binding factors PAXX and MRI. We found that PAXX and/or MRI are dispensable for such EJ. However, PAXX becomes important for blunt DSB EJ with disruption of either DNA-PKcs or XLF, whereas MRI becomes important only with XLF disruption. In contrast, while DNA-PKcs also suppresses short deletion mutations with microhomology, this effect is not magnified with PAXX loss. Finally, XLF loss causes an increase in larger deletions compared to DNA-PKcs inhibition, which is magnified with loss of MRI. We suggest that PAXX promotes DSB end synapsis in a manner that is partially redundant with DNA-PKcs and XLF, whereas MRI is a backup factor for XLF-mediated EJ.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.