ArticleWorld journal of gastrointestinal oncology2025
Impact of fibrinogen-to-albumin ratio on the long-term prognosis of patients with advanced HER2-negative gastric cancer receiving immunochemotherapy.
Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is currently no effective targeted therapy for advanced HER2-negative gastric cancer (GC). While immunotherapy combined with chemotherapy is the first-line treatment for GC, patient survival outcomes remain highly heterogeneous, highlighting the urgent need for reliable predictive biomarkers. The fibrinogen-to-albumin ratio (FAR) integrates both inflammation (elevated fibrinogen levels) and nutritional status (reduced albumin levels). Although FAR has been associated with immunotherapy resistance in various solid tumors, its prognostic value in GC patients receiving immunochemotherapy remains unclear.
aimTo assess the predictive value of the FAR in the long-term prognosis of advanced HER2-negative GC patients receiving sintilimab-based immunotherapy combined with chemotherapy.
methodsThis retrospective study included 260 patients with unresectable or metastatic HER2-negative GC who received sintilimab plus chemotherapy from 2021 to 2024. Pre-treatment FAR values were calculated, and the optimal cutoff value was determined using receiver operating characteristic curve analysis. The association between the FAR and overall survival (OS) and progression-free survival (PFS) was analyzed using Kaplan-Meier survival curves and Cox proportional hazards models. Independent prognostic factors were identified by multivariate Cox regression analysis based on OS, and a nomogram model was constructed incorporating FAR. The concordance index (C-index) and calibration curves were used to assess the predictive performance and calibration of the model.
resultsPatients with high FAR (≥ 0.08) had significantly shorter median PFS [7.80 months (6.40-8.30)
conclusionPatients with low FAR had significantly better prognostic outcomes than those with high FAR when receiving immunochemotherapy. Thus, FAR may serve as a valuable prognostic biomarker for predicting survival outcomes in patients with advanced HER2-negative GC.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.