ArticleWorld journal of gastrointestinal oncology2025
Risk of hepatocellular carcinoma according to body mass index and waist circumference in nonalcoholic fatty liver disease.
Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Clinical outcomes of lean metabolic dysfunction-associated steatotic liver disease by phenotypic subtypes.Journal of gastroenterology · 2026Article
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12 authors.
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Abstract
backgroundThe association between adiposity parameters and incident hepatocellular carcinoma (HCC) in individuals with nonalcoholic fatty liver disease (NAFLD) is yet to be evaluated.
aimTo investigate the risk of HCC according to body mass index (BMI) and waist circumference (WC) in people with NAFLD.
methodsThis population-based cohort study included Korean National Health Insurance Service examination participants with NAFLD (
resultsHCC was diagnosed in 4773 (0.43%) participants during a median follow-up of 10.3 years. A U-shaped association between BMI or WC and HCC was observed, with the highest risk observed in the lowest BMI and WC groups. Compared to normal BMI, the adjusted hazard ratio (aHR) of the underweight BMI group was 2.02 [95% confidence interval (CI): 1.25-3.28]. The lowest risk was found in groups with overweight BMI (aHR = 0.67, 95%CI: 0.60-0.73; reference: normal BMI) and WC: 85-89.9/80-84.9 cm for men/women (aHR = 0.55, 95%CI: 0.49-0.63; reference: < 80/< 75 cm). Subgroup analyses of age, sex, health behaviors, and fatty liver index showed consistent results.
conclusionThe development of HCC shows a U-shaped relationship with BMI and WC in people with NAFLD, with the highest risk in underweight individuals.
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