Evidence map›Paper›PMID 40547701›Full record

ArticleACS omega2025

One-Pot Expression and Assembly of Resurfaced Zika Virus E Domain III Nanoparticle Immunogens in Mammalian Cells.

Helen S Jung, Chowdhury Raihan Bikash, Kevin L Tao, Jonathan R Lai

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Helen S JungDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.ORCID https://orcid.org/0000-0003-0863-6460
Chowdhury Raihan BikashDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Kevin L TaoDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.ORCID https://orcid.org/0000-0002-3300-2438
Jonathan R LaiDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.

Funding

Medical Scientist Training ProgramT32GM149364 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Myles H. Akabas · 2023 to 2026
$7.5M
Structure-based design of broad flavivirus immunogensR01AI158194 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI LAI, JONATHAN R. · 2021 to 2025
$3.7M
Strategies for next-generation flavivirus vaccine developmentF30AI174788 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI JUNG, HELEN S · 2023 to 2025
$158k
NIAID NIH HHS F30 AI174788NIAID NIH HHS R01 AI158194NIGMS NIH HHS T32 GM149364
6 · The paper itself

Abstract

The presentation of antigens on self-assembling nanoparticles is a promising approach for augmenting the B-cell response of vaccines. In many cases, the nanoparticle and antigen are recombinantly expressed and purified separately prior to conjugation, requiring multiple steps that may be inefficient for large-scale production. Here, we describe a genetically encodable method and "one-pot" production of nanoparticle immunogens from mammalian cells. Our approach relies on the

Identifiers

PMID40547701
PMCPMC12177739

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.