Evidence map›Paper›PMID 40547926›Full record

ArticleFrontiers in medicine2025

Correlations between tear lymphocytotoxin-a (LT-α) level and disease severity in adult keratoconus.

Xiuxian Qin, Shunrong Luo, Xie Fang, Xianwen Xiao, Zhiwen Xie, Xumin Shang, Juan Yang, Xi Lan, Huping Wu, Zhirong Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiuxian QinXiamen Eye Center and Eye Institute of Xiamen University, Xiamen, China.
Shunrong LuoXiamen Eye Center and Eye Institute of Xiamen University, Xiamen, China.
Xie FangXiamen Eye Center and Eye Institute of Xiamen University, Xiamen, China.
Xianwen XiaoXiamen Eye Center and Eye Institute of Xiamen University, Xiamen, China.
Zhiwen XieXiamen Eye Center and Eye Institute of Xiamen University, Xiamen, China.
Xumin ShangXiamen Eye Center and Eye Institute of Xiamen University, Xiamen, China.
Juan YangXiamen Eye Center and Eye Institute of Xiamen University, Xiamen, China.
Xi LanXiamen Eye Center and Eye Institute of Xiamen University, Xiamen, China.
Huping WuXiamen Eye Center and Eye Institute of Xiamen University, Xiamen, China.
Zhirong LinXiamen Eye Center and Eye Institute of Xiamen University, Xiamen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to investigate tear lymphocytotoxin- Methods: In this cross-sectional study, tear samples from 100 keratoconus patients (KC group) and 67 healthy controls (HC group) were collected. LT-α levels were tested immediately after collection using a commercially available point-of-care test (POCT). Visual acuity, corneal tomography, anterior segment optical coherence tomography (AS-OCT), tear film parameters, including non-invasive break-up time (NI-BUT), tear meniscus height (TMH), lipid layer thickness (LLT), and meibomian glands, were also tested. Corneal topography values (K1, K2, K Results: The tear LT-α levels in the HC group were significantly higher than those in the KC group ( Conclusion: Our data demonstrated an association between tear LT-α levels and the severity of keratoconus, implying that immune-related factors may be involved in the pathogenesis and progression of the disease.

Indexed as

corneal tomographyinflammationkeratoconuslymphotoxin-α (LT-α)point-of-care testtear film

Identifiers

PMID40547926
PMCPMC12178849

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.