Evidence map›Paper›PMID 40548057›Full record

ReviewFrontiers in pharmacology2025

Regulation of transient receptor potential ankyrin 1 by traditional Chinese medicine drugs and their active ingredients.

Yunlong Fang, Chunxin Lei, Zihan Wang, Longxiao Liu, Yanyu Chen, Feng Chen, Jingxuan Li, Zhikun Tu, Qingwen Tao, Yuan Xu

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yunlong FangNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, China.
Chunxin LeiNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, China.
Zihan WangNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, China.
Longxiao LiuNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, China.
Yanyu ChenNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, China.
Feng ChenNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, China.
Jingxuan LiNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, China.
Zhikun TuNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, China.
Qingwen TaoNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, China.
Yuan XuNational Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transient receptor potential ankyrin 1 (TRPA1) has attracted substantial attention for its role as a thermal receptor and regulator of temperature and pain sensing. Notably, Traditional Chinese Medicine (TCM) has demonstrated pharmacological effects through regulation of TRPA1. In this review, we summarize the regulatory effects of TCM drugs and their active ingredients on TRPA1. A total of 31 TCM drugs were identified and categorized into three groups based on their function. Despite the progress in understanding the regulatory effects of TCM drugs and their constituents on TRPA1, further studies are needed to elucidate the molecular mechanisms involved. This review provides a molecular basis for the pharmacological effects of TCM drugs on TRPA1 regulation and offers evidence to support future research in this area.

Indexed as

Chinese herbal medicinal propertieshyperalgesiainflammatory diseasenatural compoundspaintraditional Chinese medicineTRPA1

Identifiers

PMID40548057
PMCPMC12179205

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.