Evidence map›Paper›PMID 40548579›Full record

ArticleASAIO journal (American Society for Artificial Internal Organs : 1992)2026

Computational and Experimental Assessment of Shear-Induced Blood Trauma by HeartMate II, HeartMate 3, and BrioVAD.

Anik Tarafder, Dong Han, Bartley P Griffith, Zhongjun J Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ASAIO journal (American Society for Artificial Internal Organs : 1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anik TarafderFrom the Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.ORCID 0009-0008-3341-2040
Dong HanFrom the Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Bartley P GriffithFrom the Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Zhongjun J WuFrom the Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.

Funding

First-in-Human Use of an Artificial Lung for Ambulatory Respiratory SupportR01HL118372 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI GRIFFITH, BARTLEY P, WU, ZHONGJUN JON · 2013 to 2023
$7.9M
Computational Modeling of Device-Induced Platelet Activation and Receptor Shedding Relevant to Thrombosis and Bleeding in Device-Assisted CirculationR01HL162940 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Zhongjun Jon Wu · 2023 to 2026
$2.0M
High Mechanical Shear Stress-Induced Neutrophil Dysfunction in Mechanically Assisted CirculationR01HL171120 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Zhongjun Jon Wu · 2024 to 2026
$1.8M
NHLBI NIH HHS R01 HL118372NHLBI NIH HHS R01 HL162940NHLBI NIH HHS R01 HL171120
6 · The paper itself

Abstract

Although durable mechanical circulatory support (MCS) has been promising in supporting advanced heart failure patients, device hemocompatibility-related complications remain a major concern compared with heart transplantation. We investigated the blood damage potential of the three most recent clinically available, implantable MCS devices and compared their biocompatibility performance. One axial pump (HeartMate II) and two centrifugal pumps (HeartMate 3 and BrioVAD) were chosen for this study. In vitro experiments with healthy human blood and computational fluid dynamics simulations were performed to compare high-mechanical shear-induced blood trauma in these devices. Regions of higher shear stresses were identified. Power-law relations between shear stress and blood damage were implemented to assess hemolysis, platelet activation, and platelet receptor shedding of key functional receptors (glycoprotein [GP] Ibα, and GPVI) caused by these devices. HeartMate II caused the most severe blood trauma among these three devices, producing an order of magnitude larger values for hemolysis and platelet activation compared with HeartMate 3 and BrioVAD. Also, HeartMate II consistently exhibited the highest levels of receptor shedding, approximately double those caused by the HeartMate 3 and BrioVAD. The HeartMate 3 and BrioVAD centrifugal pumps showed similar performance in terms of blood damage.

Indexed as

Heart-Assist DevicesComputer SimulationHemolysisHumansHydrodynamicsMaterials TestingPlatelet ActivationStress, MechanicalBrioVADcomputational fluid dynamicsHeartMate 3HeartMate IIleft ventricular assist deviceplatelet activationrotary blood pumpsshear-induced blood trauma

Identifiers

PMID40548579
PMCPMC12406701

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.