Evidence map›Paper›PMID 40548751›Full record

ArticleJournal of virology2025

METTL3 regulates PRRSV replication by suppressing interferon beta through autophagy-mediated IKKε degradation.

Yunyun Zhai, Lucai Wang, Lijie Lv, Xuyang Zhao, Mengjie Li, Jiajing Tian, Xiangqi Qiu, Lulu Yao, Wenhui Zhu, Yunzhe Kang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yunyun ZhaiInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Lucai WangInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Lijie LvInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Xuyang ZhaoInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Mengjie LiInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Jiajing TianInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Xiangqi QiuInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Lulu YaoInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Wenhui ZhuInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Yunzhe KangInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Angke ZhangInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Guoqing ZhuangInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.ORCID 0000-0002-9460-4379
Aijun SunInternational Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.ORCID 0000-0003-0414-9489

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methyltransferase-like-3 (METTL3)-mediated N6-methyladenosine (m

Indexed as

AutophagyI-kappa B KinaseInterferon-betaMethyltransferasesPorcine Reproductive and Respiratory SyndromePorcine respiratory and reproductive syndrome virusVirus ReplicationAdenosineAnimalsCell LineHumansImmunity, InnateProteolysisSwineAdenosineI-kappa B KinaseInterferon-betaMethyltransferasesN-methyladenosineIKKεMETTL3N6-methyladenosine (m6A)PRRSVSQSTM1/p62type I interferon

Identifiers

PMID40548751
PMCPMC12282061

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.