ArticleCellular and molecular life sciences : CMLS2025
How allosteric mutations control ligand binding in Lipocalin protein: odorant binding protein as a test case.
Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Beyond olfaction: New insights into human odorant binding proteins.Protein science : a publication of the Protein Society · 2026Review
- Structural Remodeling of Phage φPNJ-6 Hoc Promotes Adhesion to the Intestinal Epithelium.Transboundary and emerging diseases · 2026Article
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Authors and funding
12 authors.
Funding
Abstract
Lipocalins are a family of proteins found in mammals that are essential for the binding and transport of various molecules, but the mechanisms underlying their target recognition are still unclear. To answer this question, we studied odorant-binding proteins (OBPs), a specific type of lipocalin involved in chemical communication and olfaction. Using an integrative approach combining numerical modelling and experimental validation, we identified key structural regions that regulate the entry of molecules into the binding pocket. Modification of these regions disrupts molecular recognition, highlighting their importance for function. In addition, we found that changes in distant parts of the protein influence binding, shedding light on allosteric mechanisms. These results advance our understanding of lipocalin function and open up avenues for the design of proteins with targeted binding properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.