Evidence map›Paper›PMID 40549202›Full record

ArticleArchives of osteoporosis2025

Exploring the shared genetic architecture of type 2 diabetes mellitus and bone mineral density.

Xinran Feng, Hongbin Xu, Qian Guo, Zeying Wang, Ruikai Ba, Kun Xuan, Jinghao Ban

Erratum issuedAbstract read
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In one paragraph

Article in Archives of osteoporosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Xinran Feng *Second Medical Center, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Hongbin Xu *Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Qian GuoDepartment of Rhinology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Zeying WangDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Disease, Haidian District, 22 Zhongguancun Avenue South, Beijing, 100081, China.
Ruikai BaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Kun XuanState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Jinghao BanState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China. jinghaoban@163.com.

Funding

Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center LCB202009Natural Science Foundation for Young Scientists of Shanxi Province 81701030
6 · The paper itself

Abstract

There is a link between type 2 diabetes mellitus (T2DM) and bone mineral density (BMD), but the genetic reasons behind it are not yet clear. Our study found shared genetic markers and key genes connecting T2DM and BMD. This finding helps us understand their co-occurrence and may lead to new therapeutic strategies. PURPOSE: To explore the genetic correlation, causal relationships, and shared risk loci with potential functions between T2DM and BMD.

methodsUsing data from genome-wide association studies (GWAS), we explored the genetic correlation and causality between T2DM and BMD through linkage disequilibrium score regression and bidirectional Mendelian randomization. The phenotype-cell-gene association (PCGA) platform was employed to investigate single-nucleotide polymorphism (SNP) enrichment at the tissue and cell-type levels. Shared risk SNPs were identified through cross-trait meta-analyses and Heritability Estimation from Summary Statistics. We further explored biologically relevant genes using summary-data-based Mendelian randomization (SMR).

resultsOur study revealed a significant positive genetic correlation between T2DM and BMD (r

conclusionsThese discoveries elucidate the intertwined genetic structures of T2DM and BMD, enhancing our comprehension of the co-occurrence of T2DM and osteoporosis and paving the way for the innovation of targeted therapeutic strategies.

Indexed as

Bone DensityDiabetes Mellitus, Type 2Genetic Predisposition to DiseaseGenome-Wide Association StudyHumansLinkage DisequilibriumMendelian Randomization AnalysisPolymorphism, Single NucleotideBone mineral densityMendelian randomizationShared genetic architectureType 2 diabetes mellitus

Identifiers

PMID40549202

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.