Evidence map›Paper›PMID 40549549›Full record

ArticleAmerican journal of physiology. Cell physiology2025

Contribution of pannexin channels to afterimage signals in the amphibian retina.

Yufei Liu, Nick Libian, Zheng Jiang, Wen Shen

Abstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yufei LiuDepartment of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida, United States.
Nick LibianDepartment of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida, United States.
Zheng JiangDepartment of Ophthalmology, Baylor College of Medicine, Houston, Texas, United States.ORCID 0009-0009-7359-3875
Wen ShenDepartment of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida, United States.ORCID 0000-0002-0356-7120

Funding

A new strategy for vision restoration based on melanopsin transduction mechanismsR01EY034223 · NEI · BAYLOR COLLEGE OF MEDICINE · PI JIANG, ZHENG · 2022 to 2025
$1.6M
Interplexiform Cell FunctionR01EY014161 · NEI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI SHEN, WEN · 2002 to 2005
$1.1M
HHS | NIH | National Eye Institute (NEI) EY034223HHS | NIH | National Eye Institute (NEI) EY14161National Science Foundation (NSF) IOS1021646National Science Foundation (NSF) IOS2126141NEI NIH HHS R01 EY014161NEI NIH HHS R01 EY034223
6 · The paper itself

Abstract

Pannexin 1 (Panx1) forms large-pore, single-membrane channels that connect the intracellular and extracellular environments, permitting the passage of ions and small molecules, such as ATP. Panx1 channels are involved in diverse signaling pathways that contribute to various physiological processes, including sensory processing, although their precise mechanisms of action remain incompletely understood. This study reveals a Panx1-mediated mechanism regulating visual signal processing in the amphibian retina. Using immunolabeling and confocal imaging, we localized Panx1 channels in the cone-dominated On-bipolar cells, specifically at both somas and axon terminals. Whole cell patch-clamp recordings showed that these channels have high permeability to Cl

Indexed as

ConnexinsNerve Tissue ProteinsRetinaRetinal Bipolar CellsAnimalsRetinal Ganglion CellsSignal TransductionXenopus laevisConnexinsNerve Tissue Proteinsafterimagesbipolar cellsganglion cellsPannexinretina

Identifiers

PMID40549549
PMCPMC12515377

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.