Evidence map›Paper›PMID 40551021›Full record

ArticleNature chemical biology2025

A class of benzofuranoindoline-bearing heptacyclic fungal RiPPs with anticancer activities.

Qiuyue Nie, Fanglong Zhao, Xuerong Yu, Mithun C Madhusudhanan, Caleb Chang, Siting Li, Sandipan Roy Chowdhury, Bryce Kille, Andy Xu, Rory Sharkey and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Comparative Whole-Genome Sequence Analysis ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Structure, biosynthesis, and bioactivity of nostolysamides.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. A speedy cocktail.Nature chemical biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Qiuyue NieDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-2805-1462
Fanglong ZhaoDepartment of Chemical and Biomolecular Engineering, Rice University, Houston, TX, USA.
Xuerong YuDepartment of Chemistry, Rice University, Houston, TX, USA.ORCID http://orcid.org/0000-0002-6599-235X
Mithun C MadhusudhananDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA.
Caleb ChangDepartment of Biosciences, Rice University, Houston, TX, USA.
Siting LiDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sandipan Roy ChowdhuryThe Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-5246-8594
Bryce KilleDepartment of Computer Science, Rice University, Houston, TX, USA.
Andy XuDepartment of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-2428-3266
Rory SharkeyDepartment of Biosciences, Rice University, Houston, TX, USA.
Chunxiao SunDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA.
Hongzhi ZengDepartment of Chemical and Biomolecular Engineering, Rice University, Houston, TX, USA.ORCID http://orcid.org/0000-0002-9065-4109
Shuai LiuDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA.
Dishu ZhouDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Xin YuThe Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA.
Kevin YangDepartment of Chemistry, Rice University, Houston, TX, USA.ORCID http://orcid.org/0009-0004-9461-2645
Sandra A C FigueiredoInterdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Matosinhos, Portugal.ORCID http://orcid.org/0000-0001-7949-0513
Maria ZotovaDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA.
Zichen HuDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA.
Alan Y DuDepartment of Chemical and Biomolecular Engineering, Rice University, Houston, TX, USA.
Dongyin GuanDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-2641-3095
Rui TangDepartment of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-6950-9580
Todd TreangenDepartment of Computer Science, Rice University, Houston, TX, USA.
Jin WangThe Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0003-3625-7919
Pedro N LeãoInterdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Matosinhos, Portugal.ORCID http://orcid.org/0000-0001-5064-9164
Yang GaoDepartment of Biosciences, Rice University, Houston, TX, USA.ORCID http://orcid.org/0000-0002-4037-0431
Junjie ChenDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-1493-2189
Peng LiuDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA.
Hans RenataDepartment of Chemistry, Rice University, Houston, TX, USA.
Xue GaoDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA. xuegao@seas.upenn.edu.

Funding

HOUSTON AREA MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008280 · NIGMS · RICE UNIVERSITY · PI WENSEL, THEODORE G · 1988 to 2023
$8.0M
Exploring DNA damage response pathways as targets for cancer therapyR35CA274234 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Junjie Chen · 2022 to 2026
$4.4M
Computational Models for Reactivity and Selectivity in Transition Metal-Catalyzed Olefin FunctionalizationR35GM128779 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peng Liu · 2018 to 2026
$2.9M
Undergraduate Summer Research ExperienceR35GM138207 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Xue Gao · 2020 to 2026
$2.4M
NCI NIH HHS R35 CA274234NIGMS NIH HHS R35 GM128779NIGMS NIH HHS R35 GM138207NIGMS NIH HHS T32 GM008280U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM138207
6 · The paper itself

Abstract

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a promising source of new pharmaceuticals, yet the therapeutic potential of fungal RiPPs remains largely underexplored. Here we report asperigimycins as a distinct class of fungal RiPPs, featuring a unique heptacyclic scaffold consisting of a benzofuranoindoline core and three additional macrocycles, primarily assembled by six distinct fungi-specific DUF3328 oxidases. Inspired by the enhancement of anticancer activity through the N-terminal pyroglutamate in naturally occurring asperigimycins C and D, we chemically modify the inactive asperigimycin B with a series of lipid substitutions at its N-terminus. A derivative with a C-11 linear fatty acid, 2-L

Indexed as

Antineoplastic AgentsFungiIndolesPeptidesCell Line, TumorHumansProtein Processing, Post-TranslationalAntineoplastic AgentsIndolesPeptides

Identifiers

PMID40551021
PMCPMC13401907

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.