SynthesisEuropean journal of medical research2025
Efficacy and safety of statins, ezetimibe, and fibrates monotherapy or combination therapy for hyperlipidemia: a systematic review and network meta-analysis.
Synthesis in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Alternate-day alternating monotherapy (q48h) versus daily concomitant atorvastatin-fenofibrate in adults with type 2 diabetes and mixed dyslipidemia: a 12-week randomized non-inferiority trial.BMC endocrine disorders · 2026Trial
- Comparison of pharmacokinetics and safety of fixed-dose versus loose combination of atorvastatin/fenofibrate 10/145 mg in healthy Korean participants.Translational and clinical pharmacology · 2026Article
- Effects of Cricket Powder Supplementation on Gut Microbiota in High-Fat Diet-Fed Mice.Foods (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As commonly used lipid-lowering drugs, the efficacy and safety of statins, ezetimibe, and fibrates, either alone or in combination, have rarely been systematically evaluated. Therefore, we conducted a network meta-analysis to assess their efficacy and safety in patients with hyperlipidemia. In this study, we searched PubMed, the Cochrane Library, and Web of Science within our system. We included randomized controlled trials (RCTs) that compared the monotherapy or combination therapy of statins, ezetimibe, and fibrates for hyperlipidemia. Data analysis was performed using Stata 17.0 software. Each result is presented as the mean difference (MD) or odds ratio (OR) along with the 95% confidence interval (CI) and the surface under the cumulative ranking curve (SUCRA). A total of 30 studies, involving 10,219 patients, were included to analyze 12 different interventions. Combination therapy demonstrated superior therapeutic effects compared to monotherapy. Moderate-intensity statin + ezetimibe showed good efficacy and acceptable safety in reducing LDL cholesterol, while moderate-intensity statin + fibrate was a better choice for treating mixed dyslipidemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.