ArticleInternational journal of general medicine2025
Investigating the Relationship between Ulcerative Colitis and Circadian Rhythm Genes Using Bioinformatics Analysis and Machine Learning.
Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Recent Advances in Artificial Intelligence for Endoscopic and Multimodal Assessment of Inflammatory Bowel Disease: A Review.International journal of general medicine · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study investigated the correlation between circadian rhythm genes and ulcerative colitis (UC), aiming to identify biomarkers linked to immune microenvironment changes in UC. Methods: Gene expression data from UC patients and healthy controls were obtained from the GEO database. Data preprocessing included batch correction and PCA for consistency assessment. Differentially expressed genes (DEGs) were identified using the "limma" package, and functional enrichment analysis was performed. Machine learning methods (LASSO, SVM, RF) refined candidate biomarkers. RNA sequencing in a mouse colitis model and immune infiltration analysis validated key genes. A regulatory network of lncRNA, miRNA, and mRNA for hub genes was constructed. Results: 805 DEGs were identified, including 15 rhythm genes. Four key genes ( Conclusion: Disruptions in circadian rhythm are closely associated with the pathogenesis of ulcerative colitis (UC). The biomarkers
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