ArticleCureus2025
Clinical Outcomes and Magnetic Resonance Imaging Evaluation of Autologous Protein Solution Treatment for Knee Osteoarthritis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Advances in cartilage imaging techniques.Nature reviews. Rheumatology · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to investigate the clinical outcomes and magnetic resonance imaging evaluation (MRI) of intra-articular injection of autologous protein solution (APS) in patients with knee osteoarthritis of varying severities.
methodsA retrospective analysis was conducted on the clinical data of consecutive subjects with knee osteoarthritis (KOA) of varying Kellgren-Lawrence (KL) grades who underwent a single APS injection. The Knee injury and Osteoarthritis Outcome Score (KOOS), covering symptoms (S), pain (P), activity (A), sports (SP), and quality of life (Q), was used to evaluate the patients at pre-treatment and 12 months post-treatment. Minimal Clinically Important Difference (MCID) and Osteoarthritis Research Society International Set Responder Criteria Osteoarthritis Clinical Trials Revisited (OMERACT-OARSI) tools were used to observe improvement in different KL grades. Additionally, an MRI was performed pre-treatment and 12 months post-treatment. Semi-quantitative analysis (Magnetic Resonance Imaging Osteoarthritis Knee Score (MOAKS)) was applied to assess bone marrow lesions (BMLs), articular cartilage, osteophytes, synovitis and effusion, and meniscal lesions in various subregions of the knee joint.
resultsA total of 53 patients (66 knees) were included in the final analysis. At 12 months post-treatment, overall KOOS scores showed improvement. The responder rates were 78.6% (11 knees) in KL2, 68.4% (13 knees) in KL3, and 51.5% (17 knees) in KL4. Significant improvements were observed in KOOS-S, KOOS-P, and KOOS-Q across all patients. KOOS-A and KOOS-SP demonstrated statistically significant differences only in the KL2 and KL4 groups (P < 0.05). Comparisons of KOOS score differences between groups revealed that patients in the KL2 group experienced greater improvements in activity levels and quality of life compared to those in the KL3 and KL4 groups (P < 0.05). MOAKS evaluation revealed no significant improvement in cartilage damage, BMLs, synovitis-effusion, and meniscal status. In the KL4 group, the post-treatment scores for patellar superior and inferior osteophytes were higher than the pre-treatment scores (P = 0.039).
conclusionThis study provides evidence supporting the clinical efficacy of a single intra-articular injection of APS in KOA. However, the therapeutic effect of APS for structural changes in imaging remains limited.
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