Evidence map›Paper›PMID 40552262›Full record

ArticleFrontiers in oncology2025

Personalized preventive medicine using genomic information: future perspective and corresponding research plan.

Hiroto Narimatsu, Kaname Watanabe, Ann Sato, Eri Haneda, Masumi Okamoto, Haruka Nakada, Sho Nakamura

Abstract read
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hiroto NarimatsuDepartment of Genetic Medicine, Kanagawa Cancer Center, Yokohama, Japan.
Kaname WatanabeDepartment of Genetic Medicine, Kanagawa Cancer Center, Yokohama, Japan.
Ann SatoDepartment of Genetic Medicine, Kanagawa Cancer Center, Yokohama, Japan.
Eri HanedaDepartment of Genetic Medicine, Kanagawa Cancer Center, Yokohama, Japan.
Masumi OkamotoCancer Prevention and Control Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan.
Haruka NakadaGraduate School of Health Innovation, Kanagawa University of Human Services, Kawasaki, Japan.
Sho NakamuraDepartment of Genetic Medicine, Kanagawa Cancer Center, Yokohama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Personalized cancer screening guided by genomic information holds the potential for effective cancer prevention. However, current approaches face challenges, including the low risk associated with most genetic variants and limited experience in genetic counseling for healthy individuals. We are initiating a feasibility study that employs a germline cancer genomic panel of 30-80 high-risk cancer genes, such as BRCA1 and BRCA2, to identify individuals with pathogenic variants. Genetic counseling will be conducted by certified medical doctors and genetic counselors utilizing the Kanagawa Prospective "ME-BYO" Cohort Study. This initiative seeks to adapt hereditary cancer counseling practices to preventive medicine, addressing the differences in counseling between clinical and preventive settings. It aims to establish a framework for personalized cancer screening, contributing to future guidelines for identifying individuals at high risk of hereditary cancers. This research will help bridge the gap between genomic research and practical preventive medicine, paving the way for personalized cancer screening strategies based on genetic information.

Indexed as

artificial intelligencebreast cancercancer screeninggerm-line cellshereditary tumor

Identifiers

PMID40552262
PMCPMC12183036

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.