Evidence map›Paper›PMID 40552294›Full record

ArticleFrontiers in immunology2025

Dual roles of

Min-Hao Zeng, Sarah Alsobaie, Xiao-Xu Wang, Shan Li, Fahad M Aldakheel, Mourad A M Aboul-Soud, Wei-Bin Liu

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Min-Hao ZengZhejiang Provincial Key Laboratory of Aquatic Resources Conservation and Development, College of Life Science, Huzhou University, Huzhou, China.
Sarah AlsobaieDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Xiao-Xu WangSchool of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, China.
Shan LiPrecision Preventive Medicine Laboratory of Basic Medical School, Jiujiang University, Jiujiang, Jiangxi, China.
Fahad M AldakheelDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Mourad A M Aboul-SoudDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Wei-Bin LiuZhejiang Provincial Key Laboratory of Aquatic Resources Conservation and Development, College of Life Science, Huzhou University, Huzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Anisakis infections have become a significant public health concern primarily caused by consuming raw or undercooked seafood. This in is due to a shift in global eating habits, and seafood consumption is becoming increasingly popular. Materials and Methods: This study explores how Results: This study showed that ABP with LPS greatly upregulated TNF-α, boosting inflammation. Conversely, glycoproteins suppressed TNF-α transcription and reduced IL-4-induced Arg-1 expression, displaying immunosuppression. Transcriptomics analysis found that ABP enriched TNF and hematopoietic pathways, with IL6 and IL1β as key pro-inflammatory genes. Glycoproteins activated cytokine-cytokine receptor interactions and hampered leukocyte migration by downregulating Ccl2 and H3c7. Notably, ABP and glycoproteins differentially regulated the JAK-STAT pathway. Conclusion: This study shows that

Indexed as

AnisakiasisAnisakisHelminth ProteinsMacrophagesAnimalsCytokinesGene Expression ProfilingGlycoproteinsMiceRAW 264.7 CellsCytokinesGlycoproteinsHelminth ProteinsAnsiakis pegreffiiglycoproteinsinflammationmacrophage polarizationtranscriptomics

Identifiers

PMID40552294
PMCPMC12183258

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.