ArticleMethods in molecular biology (Clifton, N.J.)2025
In Vitro Models to Compare the Duration of Action of New Therapeutic Scaffolds and Drug Eluting Medical Devices.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Local therapies are in development for targeting of brain tumors and cancer stem cells, as well as non-brain tumors, due to significant transport barriers that hinder sufficient drug accumulation at the disease site. For chemotherapeutics, local delivery is already a well-established practice in the clinic for brain tumors. For immunotherapy applications, local therapies can include the delivery of immune cell engagers, adoptive cell therapies, or combination therapies to encourage adaptive responses. The duration of action of local therapies is important to extend and screen to identify efficacious formulations with a single or minimal administration. To this end, this chapter discusses the development of three-dimensional embedded multi-cellular spheroid models to track spheroid killing in real time and to screen the extended duration of action of local T cell engagers with new therapeutic scaffolds and drug eluting medical devices.
Indexed as
Identifiers
40553285What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.