ArticleThe Journal of pharmacology and experimental therapeutics2025
Locomotor and discriminative stimulus effects of fluorinated analogs of amphetamine and methamphetamine in mice and rats.
Article in The Journal of pharmacology and experimental therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The prevalence of fluorinated amphetamine and methamphetamine analogs on the illicit market has continued to increase in the past decade. The perceived ability of these compounds to bypass legal regulation has resulted in an increasing popularity among drug users; however, their use produces significant adverse effects, including heart failure, cerebral hemorrhage, and death. This study aimed to investigate the effects of phenyl ring fluorination on the abuse potential of 5 synthetic stimulant compounds: 2- and 3-fluoroamphetamine (FA) and 2-, 3-, and 4-fluoromethamphetamine (FMA). The open-field assay was used to observe the locomotor effects of the compounds and to evaluate effective dose ranges and time courses for psychoactive effects in male Swiss-Webster mice. Discriminative stimulus effects were evaluated using male Sprague-Dawley rats trained to discriminate methamphetamine from saline using an fixed-ratio 10 food-maintained reinforcement schedule in a 2-lever operant box. The compounds tested all resulted in time- and dose-dependent stimulation of locomotor activity. Potencies (ED
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