Article in Science signaling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Trayambak PathakDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.ORCID 0000-0002-0719-2995
J Cory BensonDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.ORCID 0000-0002-1446-9972
Martin T JohnsonDepartment of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Ping XinDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.ORCID 0009-0001-3638-9244
Ahmed Emam AbdelnabyDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Vonn WalterDepartment of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0001-6114-6714
Walter A KoltunDepartment of Surgery, Division of Colon and Rectal Surgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Gregory S YochumDepartment of Surgery, Division of Colon and Rectal Surgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Nadine HempelUPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.ORCID 0000-0002-5574-8783
Mohamed TrebakDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.ORCID 0000-0001-6759-864X
Funding
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
Ca2+ Signaling Networks in Health and DiseaseR35HL150778 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREBAK, MOHAMED · 2020 to 2025
$5.4M
Leukotriene C4 and STIM/Orai channels in airway smooth muscle remodelingR01HL123364 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2014 to 2017
$1.5M
Store-operated Orai3 calcium channels in metabolism and obesityR00HL163403 · NHLBI · LSU HEALTH SCIENCES CENTER · PI Trayambak Pathak · 2025 to 2026
$498k
Genes and miRNAs controlled by ORAI3 in cardiovascular remodelingR21AG050072 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEBECHE, DJAMEL, TREBAK, MOHAMED · 2016 to 2017
$471k
Store-operated Orai3 calcium channels in metabolism and obesityK99HL163403 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PATHAK, TRAYAMBAK · 2022 to 2023
$209k
The Mitochondrial Sodium/Calcium Exchanger (NCLX) in Airway Smooth Muscle Remodeling during AsthmaF30HL147489 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI JOHNSON, MARTIN T · 2019 to 2022
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Loss of STIM2, but not of STIM1, drives colorectal cancer metastasis through metabolic reprogramming and the ATF4 ER stress pathway. · full record | Socratic