ArticlePLoS neglected tropical diseases2025
Unveiling fatal risk factors: Predicting hemophagocytic lymphohistiocytosis in SFTS patients.
Article in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Hyper-activated low-density neutrophil-derived NGAL predicts fatal SFTS: a multi-cohort and single-cell study.Infection · 2026Article
- Aspartate aminotransferase-to-lymphocyte ratio predicts in-hospital mortality in patients with severe fever with thrombocytopenia syndrome: a multicenter retrospective cohort study.BMC infectious diseases · 2026Observational
- Standardized LDH-to-lymphocyte ratio improves early mortality prediction in severe fever with thrombocytopenia syndrome: A 15-day competing-risk bedside model.PLoS neglected tropical diseases · 2026Article
- Development and validation of an early risk-stratification model for hemophagocytic lymphohistiocytosis in severe fever with thrombocytopenia syndrome.PLoS neglected tropical diseases · 2026Article
- Procalcitonin/albumin to urea nitrogen ratio: a novel prognostic indicator for severe fever with thrombocytopenia syndrome.BMC infectious diseases · 2026Observational
- Early Risk Factors and Clinical Characteristics of Pediatric Hemophagocytic Lymphohistiocytosis: A Single-Center Retrospective Study.Journal of inflammation research · 2026Article
- Clinical characteristics and prognostic factors in adult macrophage activation syndrome: an observational study in a Chinese cohort.Lupus science & medicine · 2025Observational
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4 authors.
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Abstract
backgroundSevere fever with thrombocytopenia syndrome (SFTS) is a zoonotic infectious disease with high mortality, and hemophagocytic lymphohistiocytosis (HLH) is one of the rare fatal complications of SFTS. Early prediction of the occurrence of HLH and the identification of prognostic factors in SFTS patients with HLH are crucial for effective clinical management.
methodsUnivariate and multivariate logistic regression were used to analyze the demographic characteristics, clinical manifestations at admission and laboratory parameters of 272 SFTS patients. The ROC curve was used to calculate the optimal critical value of each index based on the survival outcomes of patients, and the kinetic characteristics of laboratory markers predicting the prognosis of patients with HLH were analyzed.
resultsDecreased platelet count, reduced ALT/AST ratio, elevated LDH, and increased DD were identified as independent risk factors for HLH in SFTS patients. Age, fibrinogen (FIB), and procalcitonin (PCT) were independent risk factors for mortality in SFTS patients with HLH (P < 0.05). The combination of these three factors can effectively predict patient prognosis (AUC = 0.903). Patients aged ≥64 years, with FIB ≤ 2.23 g/L, and PCT ≥ 0.9 ng/ml exhibited higher mortality rates. The dynamic characteristics of PCT and FIB levels significantly differed between the survival and death groups in SFTS patients with HLH.
conclusionEarly laboratory indicators can timely identify HLH complications in SFTS patients. Close monitoring of elderly patients and regular assessment of PCT and FIB levels can effectively reduce mortality.
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